73447-06-0Relevant academic research and scientific papers
Bioactivity of azomethines derived mechanochemically from 2-amino pyridine and studies on the effect of substituents on the reaction
Sarma, Madhushree Das,Ghosh, Subhojit
, p. 1295 - 1303 (2020/12/04)
Azomethines with pyridine framework serve as excellent pharmacophore. A number of azomethine derivatives were synthesised from 2-aminopyridine and differently substituted aromatic aldehydes in excellent to almost quantitative yields through green, mechanochemical protocol. Influence of the substituents in the nuclei of aromatic aldehydes on the rate of the reaction was investigated. Presence of ortho hydroxy groups in the nucleus of aromatic aldehydes led to the completion of the reactions in almost no time with nearly quantitative yields. 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical was used to evaluate the in vitro antioxidant activity of the prepared azomethines and the results were compared with standard natural antioxidant L-ascorbic acid. Most of the derivatives showed fairly strong antioxidant property. Antibacterial activity of the prepared azomethines were examined against Bacillus subtilis (Gram-positive) and Escherichia coli (Gram-negative) strains by using agar well diffusion method. Some of the azomethines exhibited encouraging antibacterial activities.
Unassisted formation of hemiaminal ether from 4-aminopyridine and o-vanillin - experimental and theoretical study
Mielcarek,Wi?niewska,Do??ga
, p. 1189 - 1200 (2018/04/05)
The reactions between o-vanillin and three isomeric aminopyridines lead to imines of diverse spatial conformation and reactivity. The direct products of these simple reactions carried out in methanol are either imine compounds formed in the reactions of 2
Synthesis, characterization and biological study of Cu(II) complexes of aminopyridine and (aminomethyl)pyridine Schiff bases
Sobola, Abdullahi O.,Watkins, Gareth M.,Van Brecht, Bernadus
, p. 809 - 819 (2018/08/21)
The synthesis, characterization and antimicrobial activity determination of some aminopyridine- and (aminomethyl)pyridine–salicylaldimine copper(II) complexes were realized. The ligands, L1–L6, were prepared by condensing salicylalde
Synthesis, characterization, redox property and biological activity of Ru(II) carbonyl complexes containing O,N-donor ligands and heterocyclic bases
Kumar, K. Naresh,Ramesh
, p. 2913 - 2918 (2007/10/03)
Stable ruthenium(II) carbonyl complexes having the general composition [RuCl(CO)(PPh3)(B)(L)] (where B=PPh3, pyridine, piperidine or morpholine; L = anion of bidentate Schiff bases (Vanmet, Vanampy, Vanchx)) were synthesized from the reaction of [RuHCl(CO)(PPh3) 2(B)] with bidentate Schiff base ligands derived from condensation of o-vanillin with primary amines such as methylamine, 2-aminopyridine and cyclohexylamine. The new complexes were characterized by elemental analysis, IR, UV-Vis and 1H NMR spectral data. The redox property of the complexes were studied by cyclic voltammetric technique and the stability of the complexes towards oxidation were related to the electron releasing or electron withdrawing ability of the substituent in the phenyl ring of o-vanillin. An octahedral geometry has been assigned for all the complexes. In all the above reactions, the Schiff bases replace one molecule of PPh3 and hydride ion from the starting complexes, which indicate that the Ru-N bonds present in the complexes containing heterocyclic nitrogen bases are stronger than the Ru-P. The Schiff bases and their ruthenium(II) complexes have been tested in vitro to evaluate their activity against bacteria, viz., Staphylococus aureus (209p) and E. coli (ESS 2231).
Hydrogen Bonding and Tautomeric Equilibria in Schiff Bases Derived from 2-Aminopyridines: Electronic Spectral Evidence for Substituent Effects
Ranganathan, Hemalatha,Ramasami, T.,Ramaswamy, D.,Santappa, M.
, p. 127 - 130 (2007/10/02)
Schiff bases of the type C6H3(R)(OH)CH=NC5H3N(Y) have now been synthesised and evidence sought for th
