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7345-82-6 Usage


Different sources of media describe the Uses of 7345-82-6 differently. You can refer to the following data:
1. 2,3-Dimethoxycinnamic acid is used in the synthesis of (2E,2?E,2??E)-N,N?,N??-(nitrilotri-2,1-ethanediyl)tris[3-(2,3-dimethoxyphenyl)-2-propenamide].
2. trans-2,3-Dimethoxycinnamic acid was used in the synthesis of (2E,2′E,2′′E)-N,N′,N′′-(nitrilotri-2,1-ethanediyl)tris[3-(2,3-dimethoxyphenyl)-2-propenamide].

Check Digit Verification of cas no

The CAS Registry Mumber 7345-82-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,3,4 and 5 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 7345-82:
106 % 10 = 6
So 7345-82-6 is a valid CAS Registry Number.

7345-82-6 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (D2326)  trans-2,3-Dimethoxycinnamic Acid  >98.0%(T)

  • 7345-82-6

  • 25g

  • 563.00CNY

  • Detail
  • Alfa Aesar

  • (A15936)  2,3-Dimethoxycinnamic acid, predominantly trans, 98+%   

  • 7345-82-6

  • 10g

  • 338.0CNY

  • Detail
  • Alfa Aesar

  • (A15936)  2,3-Dimethoxycinnamic acid, predominantly trans, 98+%   

  • 7345-82-6

  • 50g

  • 1381.0CNY

  • Detail
  • Alfa Aesar

  • (A15936)  2,3-Dimethoxycinnamic acid, predominantly trans, 98+%   

  • 7345-82-6

  • 250g

  • 5548.0CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name trans-2,3-Dimethoxycinnamic acid

1.2 Other means of identification

Product number -
Other names (2E)-3-(2,3-Dihydrobenzo[b]furan-5-yl)prop-2-enoic acid,(2E)-3-(2,3-Dihydro-1-benzofuran-5-yl)prop-2-enoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:7345-82-6 SDS

7345-82-6Relevant articles and documents

Discovery of caffeic acid phenethyl ester derivatives as novel myeloid differentiation protein 2 inhibitors for treatment of acute lung injury

Chen, Lingfeng,Jin, Yiyi,Chen, Hongjin,Sun, Chuchu,Fu, Weitao,Zheng, Lulu,Lu, Min,Chen, Pengqin,Chen, Gaozhi,Zhang, Yali,Liu, Zhiguo,Wang, Yi,Song, Zengqiang,Liang, Guang

, p. 361 - 375 (2017/12/07)

Myeloid differentiation protein 2 (MD2) is an essential molecule which recognizes lipopolysaccharide (LPS), leading to initiation of inflammation through the activation of Toll-like receptor 4 (TLR4) signaling. Caffeic acid phenethyl ester (CAPE) from propolis of honeybee hives could interfere interactions between LPS and the TLR4/MD2 complex, and thereby has promising anti-inflammatory properties. In this study, we designed and synthesized 48 CAPE derivatives and evaluated their anti-inflammatory activities in mouse primary peritoneal macrophages (MPMs) activated by LPS. The most active compound, 10s, was found to bind with MD2 with high affinity, which prevented formation of the LPS/MD2/TLR4 complex. The binding mode of 10s revealed that the major interactions with MD2 were established via two key hydrogen bonds and hydrophobic interactions. Furthermore, 10s showed remarkable protective effects against LPS-caused ALI (acute lung injury) in vivo. Taken together, this work provides new lead structures and candidates as MD2 inhibitors for the development of anti-inflammatory drugs.

Synthesis and leishmanicidal activity of cinnamic acid esters: Structure-activity relationship

Otero, Elver,Robledo, Sara M.,Diaz, Santiago,Carda, Miguel,Munoz, Diana,Panos, Julian,Velez, Ivan D.,Cardona, Wilson

, p. 1378 - 1386 (2014/03/21)

Several cinnamic acid esters were obtained via Fischer esterification of cinnamic acids derivatives with aliphatic alcohols. Structures of the products were elucidated by spectroscopic analysis. The synthesized compounds were evaluated for antileishmanial activity against L. (V) panamensis amastigotes and cytotoxic activity was evaluated against mammalian U-937 cells. The compounds 11, 15-17, and 23, were active against Leishmania parasite and although toxic for mammalian cells, they still are potential candidates for antileishmanial drug development. A SAR analysis indicates that first, while smaller alkyl chains lead to higher selectivity indices (10, 11 vs. 12-17); second, the degree of oxygenation is essential for activity, primarily in positions 3 and 4 (17 vs. 18-20 and 22); and third, hydroxyl groups increase both activity and cytotoxicity (14 vs. 23). On the other hand, the presence of a double bond in the side chain is crucial for cytotoxicity and leishmanicidal activity (12 vs. 21). However, further studies are required to optimize the structure of the promising molecules and to validate the in vitro activity against Leishmania demonstrated here with in vivo studies.

Design and synthesis of low molecular weight compounds with complement inhibition activity

Master, Hoshang E.,Khan, Shabana I.,Poojari, Krishna A.

, p. 4891 - 4899 (2007/10/03)

An attempt was made to synthesize a series of non-cytotoxic low molecular weight compounds of varying substitutions and functionalities having pharmacophore activity like carbonyl compounds, carboxylic acid and bioisosteres like tetrazole and phenyl acrylic acid. The in vitro assay of these analogues for the inhibition of complement activity revealed significant inhibitory activity for varying substituents and, particularly, for bioisosteres, that is, tetrazole and phenyl acrylic acid derivatives.

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