734523-69-4Relevant academic research and scientific papers
Tetrazole based amides as growth hormone secretagogues
Li, James J.,Wang, Haixia,Li, Jun,Qu, Fucheng,Swartz, Stephen G.,Hernandez, Andres S.,Biller, Scott A.,Robl, Jeffrey A.,Tino, Joseph A.,Slusarchyk, Dorothy,Seethala, Ramakrishna,Sleph, Paul,Yan, Mujing,Grover, Gary,Flynn, Neil,Murphy, Brian J.,Gordon, David
, p. 2536 - 2539 (2008/12/21)
A novel series of N1 substituted tetrazole amides were prepared and showed to be potent growth hormone (GH) secretagogues. Among them, hydroxyl containing analog 31 displayed excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV
