734533-49-4

Upstream product

• 93423-94-0 (S)-1-ethyl 2-methyl 5-oxopyrrolidine-1,2-dicarboxylate 

Downstream Products

• 1552271-75-6 ((2S,2'S,5R,5’R)-1,1'-((2-hydroxy-5-methyl-1,3-phenylene)-bis-(methylene))-bis-(5-phenylpyrrolidine-2,1-diyl))-bis-(diphenyl-methanol) 
• 1552271-22-3 diphenyl[(2S,5R)-5-phenylpyrrolidin-2-yl]methanol 
• 1552271-73-4 (2S,5R)-ethyl 2-(hydroxydiphenylmethyl)-5-phenylpyrrolidine-1-carboxylate 
• 153242-44-5 methyl (2S,5R)-5-phenyltetrahydro-2H-2-pyrrolecarboxylate 
• 734533-42-7 (2S,5R)-1-ethyl 2-methyl 5-phenylpyrrolidine-1,2-dicarboxylate 

Relevant academic research and scientific papers

Development of ProPhenol ligands for the diastereo- and enantioselective synthesis of β-hydroxy-α-amino esters

A zinc-ProPhenol-catalyzed direct asymmetric aldol reaction between glycine Schiff bases and aldehydes is reported. The design and synthesis of new ProPhenol ligands bearing 2,5-trans-disubstituted pyrrolidines was essential for the success of this process. The transformation operates at room temperature and affords syn β-hydroxy-α-amino esters in high yields with good to excellent levels of diastereo- and enantioselectivity.

Synthesis of cis-2,5-disubstituted pyrrolidines via diastereoselective reduction of N-acyl iminium ions

A new procedure for forming cis-2,5-disubstituted pyrrolidines having unsaturated side chains has been developed that features the diastereoselective reduction of N-acyl iminium ions, which were formed in situ by acid-catalyzed cyclizations of unsaturated