73471-96-2

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
Ethanone, 1-(4-ethylphenyl)-2,2,2-trifluoro(9CI) is utilized as an intermediate in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and agricultural products.
Used as a Flavoring Agent in the Food Industry:
Ethanone, 1-(4-ethylphenyl)-2,2,2-trifluoro(9CI) is employed as a flavoring agent in the food industry, enhancing the taste and aroma of various food products.
Used in Perfume and Fragrance Production:
Ethanone, 1-(4-ethylphenyl)-2,2,2-trifluoro(9CI) has potential applications in the production of perfumes and fragrance products, adding unique scents and improving the overall quality of these products.
Safety Precautions:
Caution should be taken with Ethanone, 1-(4-ethylphenyl)-2,2,2-trifluoro(9CI) as it may be harmful if ingested or inhaled and can cause irritation to the skin and eyes upon contact.

Upstream product

• 100-41-4 ethylbenzene 
• 1585-07-5 1-bromo-4-ethylbenzene 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 131252-25-0 1-(4'-ethylphenyl)-2,2,2-trifluoroethanol 
• 1096375-77-7 (R)-1-(4-ethylphenyl)-2,2,2-trifluoro-1-(1H-pyrrol-2-yl)ethanol 
• 1414962-83-6 2-(4-ethylphenyl)-3,3,3-trifluoro-2-hydroxy-N-(4-methoxybenzyl)propanamide 
• 1476038-37-5 C₂₀H₂₀F₃NO₄ 
• 1476038-42-2 C₂₀H₂₀F₃NO₄ 

Relevant academic research and scientific papers

A simple method for the preparation of aryl trifluoromethyl ketones

4-Dimethylamino-1-trifluoroacetylpyridinium trifluoroacetate (2) is an effective, easy to handle and stable trifluoroacetylation agent. Aryl trifluormethyl ketones 4 are obtained in good yields by reaction of 2 with aromatic compounds 3 in the presence of aluminum chloride.

The reduction of aryl trifluoromethyl ketones by sodium borohydride. The hydride transfer process

The rates of reduction of 17 aryl trifluoromethyl ketones by sodium borohydride in 2-propanol have been measured.The rho (ρ) value is 3.12, excluding the 4-amino and 4-dimethylamino groups, which both lower the rate to a greater extent than their ? values predict.The close correspondence between substituent effects for hydride addition in the methyl and trifluoromethyl series (excluding the amino groups) suggests that normal substituent effects are to be expected for oxidation processes involving hydride removal in trifluoromethyl compounds.The present results are consistent with the oxidation of aryl trifluoromethyl carbi ols by permanganate taking place by hydrogen atom abstraction.The effect of substituents on the rate of reduction of the trifluoromethyl ketones is almost identical to that on the equilibrium constant for formation of the ketone hydrates.The application of the reactivity-selectivity principle to the reduction reaction is also considered.Reduction of the 4-ethyl compound has ΔH = 2.7 kcal mol-1 and ΔS = -38 cal deg-1 mol-1.