73483-58-6Relevant academic research and scientific papers
Synthesis of ring 14C methyl labeled retinyl acetate
Colwell,SooHoo,DeGraw
, p. 551 - 558,552,557 (1979)
A method for incorporation of a 14C-label in the ring geminal methyl moiety of Vitamin A is described. The procedure involes mono methylation of 2,6-dimethylcyclohexanone with 14C-methyl iodide as catalyzed by potassium hydride to afford 2-14C, 2,6-trimethylcyclohexanone. Subsequent condensation with an 11-carbon acetyleneic side chain, followed by reduction, acetylation and dehydration yielded 14C-retinyl acetate. Final purification was achieved by preparative thin layer chromatography.
