73495-08-6

Usage

Uses

Used in Pharmaceutical Research:
()-3-Amino-3-(2-furyl)-propionic acid is utilized as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Chelation Therapy:
Due to its ability to form stable complexes with metal ions, ()-3-Amino-3-(2-furyl)-propionic acid is used as a chelating agent in chelation therapy. This application is particularly beneficial in the treatment of heavy metal poisoning, where it helps to bind and remove toxic metal ions from the body.
Used in Metal Ion Detection:
()-3-Amino-3-(2-furyl)-propionic acid is employed as a reagent in analytical chemistry for the detection and quantification of metal ions. Its complex-forming ability with metal ions makes it a useful tool in various analytical techniques.
Used in the Treatment of Neurological Disorders:
()-3-Amino-3-(2-furyl)-propionic acid has been studied for its potential therapeutic applications in the treatment of neurological disorders. Its unique properties may contribute to the development of new treatments for conditions such as Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders.

Upstream product

• 121786-31-0 (S)-2-amino-3-(2-furanyl)propionic acid 
• 4066-39-1 (rac)-2-amino-3-furan-2-yl-propionic acid 

Downstream Products

• 78175-20-9 (R)-3-(2,4-Dinitro-phenylamino)-3-furan-2-yl-propionic acid 

Relevant academic research and scientific papers

Enhanced conversion of racemic α-arylalanines to (R)-β- arylalanines by coupled racemase/aminomutase catalysis

(Graph Presented) The Taxus phenylalanine aminomutase (PAM) enzyme converts several (S)-α-arylalanines to their corresponding (R)-β- arylalanines. After incubating various racemic substrateswith 100 μg of PAM for 20 h at 31°C, each (S)-α-arylalanine was enantioselectively isomerized to its corresponding (R)-β-product. With racemic starting materials, the ratio of (R)-β-arylalanine product to the (S)-α-substrate ranged between 0.4 and 1.8, and the remaining nonproductive (R)-α-arylalanine became enriched. To utilize the (R)-α-isomer, the catalysis of a promiscuous alanine racemase from Pseudomonas putida (KT2440) was coupled with that of PAM to increase the production of enantiopure (R)-β-arylalanines from racemic α-arylalanine substrates. The inclusion of a biocatalytic racemization along with the PAM-catalyzed reactionmoderately increased the overall reaction yield of enantiopure β-arylalanines between 4% and 19% (depending on the arylalanine), which corresponded to as much as a 63% increase compared to the turnover with the aminomutase reaction alone. The use of these biocatalysts, in tandem, could potentially find application in the production of chiral β-arylalanine building blocks, particularly, as refinements to the process are made that increase reaction flux, such as by selectively removing the desired (R)-β-arylalanine product from the reaction mixture. 2009 American Chemical Society.

β-styryl- and β-aryl-β-alanine products of phenylalanine aminomutase catalysis

The substrate specificity of a Taxus-derived phenylalanine aminomutase (PAM) was investigated, and the enzyme was found to catalyze the conversion of variously substituted vinyl- and aryl-S-∞-alanines to corresponding β-amino acids. This study shows the b