735-06-8

Usage

Uses

Used in Analytical Chemistry:
2'-FLUORO-2-METHYLAMINO-5-NITROBENZOPHENONE is used as an analyte in reversed-phase High-Performance Liquid Chromatography (HPLC) for its ability to separate and identify different components in a mixture. Its unique chemical structure allows for effective interaction with the stationary phase, enabling precise and accurate analysis of complex samples.
Additionally, 2'-FLUORO-2-METHYLAMINO-5-NITROBENZOPHENONE is used as a reference compound in UV spectrophotometry due to its characteristic absorption spectrum. This property makes it a valuable tool for calibrating and validating spectrophotometric instruments, ensuring accurate measurements and reliable results in various research and quality control applications.

Upstream product

• 1622-62-4 flunitrazepam 

Relevant academic research and scientific papers

2-amino-5-nitrobenzophenone and 2′-fluoro-2-methylamino-5-nitrobenzophenone

The title compounds, C13H10N2O3 and C14H11FN2O3, were prepared by acid degradation of the 1,4-benzodiazepine drugs nitrazepam and flunitrazepam, respectively. The structure of 2-amino-5-nitrobenzophenone reported here is a polymorphic form of a known structure.

Kinetics of the acid hydrolysis of diazepam, bromazepam, and flunitrazepam in aqueous and micellar systems

A kinetic study of the acid hydrolysis of aqueous diazepam, bromazepam, and flunitrazepam was carried out at 25 °C using a spectrophotometric method. For diazepam and flunitrazepam, the experimental pseudo first-order rate constant decreased as the acid concentration was increased. The contrary behavior was found in the case of bromazepam. A kinetic scheme that includes the hydrolysis reaction of both protonated and nonprotonated species of the drug can account for these results. Also, the kinetics of the acid hydrolysis of the same drugs in the presence of micellar aggregates [nonionic polyoxyethylene-23-dodecanol (Brij 35); cationic cetyl trymethyl ammonium bromide (CTAB); and anionic sodium decyl (SdeS), dodecyl (SDS), and tetradecyl (STS) sulfate] was studied at 25 °C. Negligible effects were observed in the cases of nonionic and cationic micelles. Anionic micelles produced an inhibitory effect in the reaction velocity. This effect increased as the hydrophobic nature of the surfactant increased. All these facts are interpreted quantitatively by means of a pseudophase model.