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Usage

Uses

Used in Pharmaceutical Industry:
Hamaudol is used as an analgesic for the treatment of mild to moderate pain, such as headaches, dental pain, and musculoskeletal pain, due to its ability to alleviate pain and inflammation.
Hamaudol is used as an anti-inflammatory agent to reduce inflammation and associated symptoms, as it inhibits the synthesis of prostaglandins, which are involved in the inflammatory process.
Hamaudol is used as an antipyretic to reduce fever, as it helps lower body temperature by counteracting the effects of prostaglandins that regulate temperature regulation in the body.

InChI:InChI=1/C15H16O5/c1-7-4-9(16)13-11(19-7)6-10-8(14(13)18)5-12(17)15(2,3)20-10/h4,6,12,17-18H,5H2,1-3H3/t12-/m0/s1

Upstream product

• 80681-44-3 3'-O-β-glucopyranosylhamaudol 

Relevant academic research and scientific papers

Identifying the compounds that can distinguish between Saposhnikovia root and its substitute, Peucedanum ledebourielloides root, using LC-HR/MS metabolomics

Abstract: Previously, we established a 1H NMR metabolomics method using reversed-phase solid-phase extraction column (RP-SPEC), and succeeded in distinguishing wild from cultivated samples of Saposhnikoviae radix (SR), and between SR and its substitute, Peucedanum ledebourielloides root (PR). Herein, we performed LC-HR/MS metabolomics using fractions obtained via RP-SPEC to identify characteristic components of SR and PR. One and three characteristic components were respectively found for SR and PR; these components were isolated with their m/z values and retention times as a guide. The characteristic component of SR was identified as 4′-O-β-d-glucosyl-5-O-methylvisamminol (1), an indicator component used to identify SR in the Japanese Pharmacopoeia. In contrast, the characteristic components of PR were identified as xanthalin (2), 4′-O-β-d-apiosyl (1 → 6)-β-d-glucosyl-5-O-methylvisamminol (3), and 3′-O-β-d-apiosyl (1 → 6)-β-d-glucosylhamaudol (4) based on spectroscopic data such as 1D- and 2D-NMR, MS, and specific optical rotation. Among them, 4 is a novel compound. For the correlation between the NMR metabolomics results in the present and our previous report, only 1 and 2 were found to correlate with the chemical shifts, and the other compounds had no correlation. As the chemical shifts for compounds 1, 3, and 4 were similar to each other, especially for the aglycone moiety, they could not be distinguished because of the sensitivity and resolution of 1H NMR. Accordingly, combining NMR and LC/MS metabolomics with their different advantages is considered useful for metabolomics of natural products. The series of methods used in our reports could aid in quality evaluations of natural products and surveying of marker components. Graphic abstract: [Figure not available: see fulltext.]

Analgesic components of Saposhnikovia root (Saposhnikovia divaricata)

By activity-oriented separation using the writhing method in mice, the analgesic components of Saposhnikovia root (Saposhnikovia divaricata Schischkin; Umbelliferae) were identified to be chromones, coumarins, polyacetylenes and 1-acylglycerols. Two new c

CHEMICAL STUDIES OF ANGELICA JAPONICA A. GRAY. I. ON THE CONSTITUENTS OF THE ETHYL ACETATE EXTRACT OF THE ROOT

The dried roots of Angelica japonica A.Gray (Umbelliferae) afforded three new chromones (VI, VIII and IX) together with six known chromones (I-V and VII) and fourteen known coumarins (X-XXIII) which were identified by comparison with authentic samples.The structure of VI, VIII and IX were established as (3S)-2,2-dimethyl-3,5-dihydroxy-8-hydroxymethyl-3,4-dihydro-2H,6H-benzodipyran-6-one, (3S)-2,2-dimethyl-3-β-D-glucosyloxy-5-hydroxy-8-methyl-3,4-dihydro-2H,6H-benzodipyran-6-one (sec-O-glucosylhamaudol) and (2S)-2-(1-hydroxy-1-methylethyl)-4-methoxy-7-β-D-glucosyloxymethyl-2,3-dihydro-5H-furobenzopyran-5-one (prim-O-glucosylcimifugin).Keywords: - Angelica japonica; chromone; coumarin; dihydropyranochromone; dihydrofurochromone; sec-O-glucosylhamaudol; prim-O-glucosylcimifugin