73509-20-3

Usage

Uses

Used in Research and Drug Development:
INDOLE-D7 is used as a stable isotope-labeled internal standard for the quantification of indole in biological samples. Its deuterated form provides accurate and reliable measurements of indole levels in complex biological matrices.
Used in Mass Spectrometry-based Studies:
INDOLE-D7 is used as a stable isotope-labeled internal standard in mass spectrometry-based studies to ensure accurate and reliable measurements of indole levels.
Used in Analytical Applications:
INDOLE-D7 is used in analytical applications due to its resistance to metabolic degradation, providing stable and consistent results.

Upstream product

• 120-72-9 indole 

Relevant academic research and scientific papers

METHOD FOR PRODUCING COMPOUND HAVING DEUTERATED AROMATIC RING OR HETEROCYCLIC RING

A method for producing a compound having a deuterated aromatic ring or heterocyclic ring according to the invention includes heating a compound having an aromatic ring or heterocyclic ring in the presence of heavy water, a transition metal and a metal which generates deuterium. As the metal which generates deuterium, at least one metal selected from the group consisting of aluminum, magnesium, zinc, iron, lead and tin is preferred. As the transition metal, at least one metal selected from the group consisting of platinum, palladium, ruthenium and rhodium is preferred. The heating is preferably carried out by microwave irradiation.

C-H bond activation by water on a palladium or platinum metal surface

A water molecule is partially cleaved on a palladium or platinum metal surface under hydrothermal conditions to form an active platinum species. The species is effective for C-H bond functionalization which can be applied for H/D-exchange reactions, C-C bond-forming reactions, and C-N bond-forming reactions. Georg Thieme Verlag Stuttgart.

Platinum catalyzed H-D exchange reaction of various aromatic compounds under hydrothermal condition

Various aromatic compounds were treated with deuterium oxide under hydrothermal conditions in the presence of a catalytic amount of platinum (IV) oxide. An efficient H-D exchange reaction was observed, which gave various deterium labeled aromatic compounds.

General method of obtaining deuterium-labeled heterocyclic compounds using neutral D2O with heterogeneous Pd/C

A protocol of a versatile H-D exchange reaction of heterocyclic compounds catalyzed by heterogeneous Pd/C in D2O is described. The reaction of various nitrogen-containing heterocycles with 10% Pd/C (10 wt % of the substrate) under hydrogen atmosphere in D2O as a deuterium source at 110-180 °C for 24 h afforded the corresponding deuterated compounds with satisfactory efficiency of deuteration in moderate to excellent isolated yields. Furthermore, the Pd/C-H2-D2O system can be extended to the direct deuteration of biologically active compounds such as sulfamethazine, which is used as a synthetic antibacterial drug for fat stocks and would be applied as a general method for the preparation of the standard materials for the analysis of residual chemicals in foods and so on.