73519-55-8

Upstream product

• 66546-20-1 4-(6-chlorobenzoxazolyloxy)phenoxypropionic acid methyl ester 
• 60075-04-9 (RS)-methyl 2-(4-hydroxyphenoxy)propionate 
• 123-31-9 hydroquinone 
• 66441-23-4 2-[4-(6-Chloro-benzooxazol-2-yloxy)-phenoxy]-propionic acid ethyl ester 
• 3621-82-7 2,6-dichloro-1,3-benzoxazole 

Relevant academic research and scientific papers

Stereoselective metabolism of fenoxaprop-ethyl and its chiral metabolite fenoxaprop in rabbits

The stereoselective metabolism of the enantiomers of fenoxaprop-ethyl (FE) and its primary chiral metabolite fenoxaprop (FA) in rabbits in vivo and in vitro was studied based on a validated chiral high-performance liquid chromatography method. The information of in vivo metabolism was obtained by intravenous administration of racemic FE, racemic FA, and optically pure (-)-(S)-FE and (+)-(R)-FE separately. The results showed that FE degraded very fast to the metabolite FA, which was then metabolized in a stereoselective way in vivo: (-)-(S)-FA degraded faster in plasma, heart, lung, liver, kidney, and bile than its antipode. Moreover, a conversion of (-)-(S)-FA to (+)-(R)-FA in plasma was found after injection of optically pure (-)-(S)- and (+)-(R)-FE separately. Either enantiomers were not detected in brain, spleen, muscle, and fat. Plasma concentration-time curves were best described by an open three-compartment model, and the toxicokinetic parameters of the two enantiomers were significantly different. Different metabolism behaviors were observed in the degradations of FE and FA in the plasma and liver microsomes in vitro, which were helpful for understanding the stereoselective mechanism. This work suggested the stereoselective behaviors of chiral pollutants, and their chiral metabolites in environment should be taken into account for an accurate risk assessment.

HERBICIDAL COMPOSITIONS

The present invention provides compositions comprising herbicidally active compounds (A) and (B), where (A) represents one or more compounds of the general formula (I) or agrochemically compatible salts thereof [component (A)], and (B) represents one or more herbicides [component (B)]. The application further relates to a method and to the use of the herbicidal composition according to the invention for controlling harmful plants or for regulating growth.

6-chlorobenzoxazoloxy phenoxyacrylamide compounds and application thereof

The invention discloses 6-chlorobenzoxazoloxy phenoxyacrylamide compounds and an application thereof as herbicides; the compounds are represented by the general formula (I), wherein W is selected fromC1-4 alkylene. The compounds not only have excellent he

6-chlorobenzoxazol-oxyphenoxy propionate compound and application thereof

The invention belongs to the field of herbicides and particularly relates to a 6-chlorobenzoxazol-oxyphenoxy propionate compound and application thereof. The compound is shown in a general formula (I). The compound provided by the invention not only has e

II. Synthesis and biological evaluation of some bioisosteres and congeners of the antitumor agent, 2-{4-[(7-chloro-2-quinoxalinyl)oxylphenoxy}propionic acid (XK469)

XK469 (1) is among the most highly and broadly active antitumor agents to have been evaluated in our laboratories. Subsequent developmental studies led to the entry of (R)-(+) 1 (NSC 698215) into phase 1 clinical trials (NIH UO1-CA62487). The antitumor me