73540-74-6

Upstream product

• 869650-92-0 Se-phenyl 1-benzyl-3-[(3-pyridyl)methyl]-2-indolecarboselenoate 
• 214066-29-2 1-Benzyl-2-[(3-bromo-pyridin-4-yl)-hydroxy-methyl]-1H-indole-3-carboxylic acid diethylamide 
• 530-40-5 N,N-diethylisonicotinamide 
• 10511-51-0 1-Benzylindole-3-carboxaldehyde 

Downstream Products

• 519-23-3 ellipticine 
• 74606-36-3 6-benzyl-5,11-dimethyl-6H-pyrido[4,3-b]carbazole 

Relevant academic research and scientific papers

Diversity-Oriented Synthesis of Calothrixins and Ellipticines

The divergent synthesis of calothrixins and ellipticines has been accomplished by utilising the one-pot formation of o-diacylarenes as a key intermediate through rearrangement of o-hydroxy ketone monoacyl hydrazones by lead tetraacetate mediated oxidation. The divergent synthesis of calothrixins and ellipticines has been accomplished by utilising the one-pot formation of o-diacylarenes as a key intermediate through rearrangement of o-hydroxy ketone monoacyl hydrazones by lead tetraacetate mediated oxidation.

Regioselective intramolecular reactions of 2-indolylacyl radicals with pyridines: A direct synthetic entry to ellipticine quinones

2-Indolylacyl radicals generated from the corresponding selenoesters under hexabutylditin-hv conditions undergo regioselective intramolecular reaction with unprotonated pyridines to give polycyclic indolylpyridyl ketones. For substrates bearing a (3-pyridyl)methyl moiety connected to the 3-position of the indole ring, the cyclization provides easy access to ellipticine quinones.

Reaction of l-benzylindole-2,3-dicarboxylic anhydride with 3-bromo-4-lithiopyridine: Formal synthesis of ellipticine

Reaction of l-benzylindole-2,3-dicarboxylic anhydride with 3-bromo-4-lithiopyridine gave 2-(3-bromoisonicotinoyl)indole-3-carboxylic acid as the sole product. The indole-3-carboxylic acid could be converted to 6-benzylellipticine quinone in five steps.