73554-80-0

Basic information

• Product Name: 2,4-diamino-5-(3,5-di-tert-butyl-4-hydroxybenzyl)pyrimidine
• Synonyms: 2,4-diamino-5-(3,5-di-tert-butyl-4-hydroxybenzyl)pyrimidine
• CAS NO: 73554-80-0
• Molecular Weight: 328.458
• Mol File: 73554-80-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,4-diamino-5-(3,5-di-tert-butyl-4-hydroxybenzyl)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-diamino-5-(3,5-di-tert-butyl-4-hydroxybenzyl)pyrimidine(73554-80-0)
• EPA Substance Registry System: 2,4-diamino-5-(3,5-di-tert-butyl-4-hydroxybenzyl)pyrimidine(73554-80-0)

Safety Data

• Hazardous Substances Data: 73554-80-0(Hazardous Substances Data)

Upstream product

• 88-27-7 N,N-dimethyl-(3,5-di-tert-butyl-4-hydroxybenzyl)amine 
• 73943-43-8 5-(3,5-di-tert-butyl-4-hydroxybenzyl)uracil 
• 128-39-2 2,6-di-tert-butylphenol 
• 4433-40-3 5-hydroxymethyl uracil 
• 73943-44-9 2,4-dichloro-5-(3,5-di-tert-butyl-4-hydroxybenzyl)pyrimidine 
• 42310-45-2 2,4-diamino-5-hydroxymethyl-pyrimidine 

Relevant articles and documents

2,4-Diamino-5-benzylpyrimidines and Analogues as Antibacterial Agents. 9. Lipophilic Trimethoprim Analogues as Antigonococcal Agents

Lipophilic analogues of trimethoprim (1) bearing 3,5-dialkyl-4-hydroxy substituents in the benzene ring are much more active in vitro against Neisseria gonorrhoeae than is 1.The 3,5-diisopropyl-4-hydroxy derivative (2) was selected as a candidate for clinical evaluation as an antigonococcal agent, and as part of the preliminary evaluation it was submitted to extended pharmacokinetic and metabolism studies in dogs.Although the compound was not extensively conjugated by metabolic enzymes, one of the methyl groups was metabolized to produce a 3-isopropyl-4-hydroxy-5-(α-carboxyethyl)benzyl derivative (43), which was rapidly excreted.Related analogues were likewise extensively metabolized.