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BOC-LEU-SER-THR-ARG-MCA is a peptide derivative labeled with a fluorogenic compound, MCA (7-methoxycoumarin-4-acetic acid). It is designed with a BOC (tert-butyloxycarbonyl) protective group at the N-terminus and consists of a sequence of amino acid residues, including leucine (LEU), serine (SER), threonine (THR), and arginine (ARG). The MCA label allows for the detection and quantification of protease activity, making it a valuable tool in biochemical and pharmaceutical research.

73554-93-5

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73554-93-5 Usage

Uses

Used in Biochemical Research:
BOC-LEU-SER-THR-ARG-MCA is used as a substrate for the cleavage activity of proteases such as chymotrypsin and trypsin. The cleavage of the peptide bond between arginine and MCA results in an increase in fluorescence intensity, providing a convenient and sensitive assay for enzyme activity.
Used in Pharmaceutical Research:
In the pharmaceutical industry, BOC-LEU-SER-THR-ARG-MCA serves as a valuable tool for the development and evaluation of protease inhibitors. By monitoring the fluorescence intensity changes upon protease cleavage, researchers can assess the potency and selectivity of potential inhibitors, aiding in the discovery of new therapeutic agents.
Used in Drug Development:
BOC-LEU-SER-THR-ARG-MCA is used as a screening tool for the identification of novel protease inhibitors. Its sensitivity and convenience make it an ideal candidate for high-throughput screening assays, enabling the rapid evaluation of large compound libraries to identify potential drug candidates.
Used in Enzyme Kinetics Studies:
BOC-LEU-SER-THR-ARG-MCA is employed as a substrate in enzyme kinetics studies to determine the catalytic efficiency and mechanism of action of proteases. By measuring the rate of fluorescence increase upon peptide bond cleavage, researchers can gain insights into the enzyme's activity and its interaction with substrates.

Check Digit Verification of cas no

The CAS Registry Mumber 73554-93-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,5,5 and 4 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 73554-93:
(7*7)+(6*3)+(5*5)+(4*5)+(3*4)+(2*9)+(1*3)=145
145 % 10 = 5
So 73554-93-5 is a valid CAS Registry Number.
InChI:InChI=1/C34H52N8O10/c1-17(2)13-23(40-33(50)52-34(5,6)7)29(47)39-24(16-43)30(48)41-27(19(4)44)31(49)42-28(46)22(9-8-12-37-32(35)36)38-20-10-11-21-18(3)14-26(45)51-25(21)15-20/h10-11,14-15,17,19,22-24,27,38,43-44H,8-9,12-13,16H2,1-7H3,(H,39,47)(H,40,50)(H,41,48)(H4,35,36,37)(H,42,46,49)/t19-,22+,23+,24+,27+/m1/s1

73554-93-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name BOC-LEU-SER-THR-ARG-MCA

1.2 Other means of identification

Product number -
Other names Boc-LSTR-AMC

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:73554-93-5 SDS

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