73559-07-6

Upstream product

• 120-92-3 cyclopentanone 
• 591-31-1 3-methoxy-benzaldehyde 

Downstream Products

• 73559-10-1 di-m-anisalcyclopent-3-en-1-one 
• 73559-06-5 2,5-bis(3-methoxybenzyl)cyclopentan-1-one 
• 73559-11-2 tetrabromodi-m-anisalcyclopentanone 
• 1566611-29-7 1,2-bis(4-(3-methoxyphenyl)-1H-pyrrol-3-yl)ethane 

Relevant academic research and scientific papers

Development of Chiral Spiro Phosphoramidites for Rhodium-Catalyzed Enantioselective Reactions

A series of 1,1′-spirobiindane-7,7′-diol (SPINOL) analogues bearing a 2,2′-dimethyl-, cyclopentyl-, or cyclohexyl-fused ring were synthesized, and their distinct structural features were elucidated by X-ray crystallography. On the basis of these scaffolds, chiral monophosphoramidite ligands 6 a–m were synthesized, which demonstrated excellent enantioselectivity in RhI-catalyzed asymmetric hydrogenation of a dehydro amino acid methyl ester. Ligands 6 a–m were also successfully applied in the RhI-catalyzed enantioselective [4+2] cycloaddition of α,β-unsaturated imines with isocyanates, which afforded the corresponding pyrimidinones in good yields (60–92 %) with high enantioselectivities (75–92 % ee).

Synthesis of new pyrazoline-nucleoside analogue derivatives

In this work, a synthesis of pyrazoline nucleosides analogues is presented, using the stereospecific sodium salt glycosylation procedure. In the first step, chalcones were prepared using Claisen Schmidt reaction by reacting benzaldehyde with enolizable ketones in ethanolic NaOH solutions. Next, these chalcones were immediately reacted with hydrazine hydrochloridein the presence of dry methanol to obtain the corresponding 2-pyrazolines. Finally, the coupling of the pyrazolines with 1-chloro-arabinofuranose leads to different β-nucleosides as the major product (13-17) in good yields. The structures of these derivatives were characterized by infrared and 1HNMR spectroscopy and mass spectrometry.

Solvent-free crossed aldol condensation of cyclic ketones with aromatic aldehydes assisted by microwave irradiation

A fast alumina-promoted crossed aldol-condensation reaction of aldehydes and cyclic ketones under microwave irradiation is described. This process is simple, efficient, and environmentally benign and proceeds in fairly high yield without any self-condensation. Springer-Verlag 2005.