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CORTISOL-9,11,12,12-D4, also known as Hydrocortisone-d4, is a deuterated internal standard used for the quantification of hydrocortisone/cortisol by gas chromatography-mass spectrometry (GC-MS) or liquid chromatography-mass spectrometry (LC-MS). It is a synthetically produced analogue of cortisol, a naturally occurring glucocorticoid hormone produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH). CORTISOL-9,11,12,12-D4 is designed to have similar chemical properties to cortisol, allowing for accurate and precise measurement of cortisol levels in various biological samples.

73565-87-4

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73565-87-4 Usage

Uses

Used in Pharmaceutical Industry:
CORTISOL-9,11,12,12-D4 is used as an internal standard for the quantification of hydrocortisone/cortisol levels in biological samples. This is crucial for the development and quality control of pharmaceutical products containing hydrocortisone or cortisol, ensuring accurate dosing and therapeutic efficacy.
Used in Clinical Diagnostics:
CORTISOL-9,11,12,12-D4 is used as a reference compound in clinical diagnostic tests to measure cortisol levels in patients. This helps in diagnosing and monitoring various conditions such as stress-related disorders, major depressive disorder, certain forms of hypertension, and Parkinson's disease, where cortisol levels may be elevated.
Used in Research:
CORTISOL-9,11,12,12-D4 is used as a research tool in scientific studies to investigate the role of cortisol in various physiological processes and disease states. It aids in understanding the complex interactions of cortisol with other hormones and signaling pathways, contributing to a better understanding of the hypothalamic-pituitary-adrenal (HPA) axis and its role in stress response.
Used in Anti-inflammatory Applications:
As a synthetic analogue of cortisol, CORTISOL-9,11,12,12-D4 can be used in research and development of anti-inflammatory drugs. Cortisol, also known as hydrocortisone when used therapeutically, is a potent anti-inflammatory hormone that suppresses the immune system and reduces inflammation. The deuterated analogue can help in the design and optimization of new anti-inflammatory agents with improved efficacy and reduced side effects.
Used in Metabolic Studies:
CORTISOL-9,11,12,12-D4 can be employed in metabolic studies to investigate the role of cortisol in regulating glucose metabolism, fat metabolism, and protein metabolism. Cortisol is known to increase blood sugar levels through gluconeogenesis and plays a crucial role in the body's response to stress. The use of CORTISOL-9,11,12,12-D4 in these studies can provide valuable insights into the mechanisms of cortisol action and its impact on overall metabolic health.

Check Digit Verification of cas no

The CAS Registry Mumber 73565-87-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,5,6 and 5 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 73565-87:
(7*7)+(6*3)+(5*5)+(4*6)+(3*5)+(2*8)+(1*7)=154
154 % 10 = 4
So 73565-87-4 is a valid CAS Registry Number.
InChI:InChI=1/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15?,16-,18?,19-,20-,21?/m0/s1/i10D2,16D,18D

73565-87-4 Well-known Company Product Price

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  • Cerilliant

  • (C-113)  Cortisol-D4 (9,11,12, 12-D4) solution  100 μg/mL in methanol, ampule of 1 mL, certified reference material

  • 73565-87-4

  • C-113-1ML

  • 4,811.04CNY

  • Detail

73565-87-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name (8S,10R,11S,13S)-9,11,12,12-tetradeuterio-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

1.2 Other means of identification

Product number -
Other names cortisol-d4

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:73565-87-4 SDS

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