73569-46-7

Upstream product

• 108-24-7 acetic anhydride 
• 87080-27-1 licochalcone A 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 870-63-3 prenyl bromide 
• 61235-37-8 2-hydroxy-4-(3-methylbut-2-enyloxy)benzaldehyde 
• 151410-32-1 (2E)-1-(4-hydroxyphenyl)-3-{2-methoxy-4-[(3-methylbut-2-en-1-yl)oxy]phenyl}prop-2-en-1-one 
• 73569-44-5 2-methoxy-4-[(3-methylbut-2-en-1-yl)oxy]benzaldehyde 

Downstream Products

• 87080-27-1 licochalcone A 

Relevant academic research and scientific papers

Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B

Compounds (1-6) isolated from the CH2Cl2 extract of Glycyrrhiza inflata and semisynthetic licochalcone A derivatives (7-14) were evaluated for their protein tyrosine phosphatase 1B (PTP1B) inhibitory activities. Licochalcones A (4) a

Synthesis of licochalkone-A

Claisen rearrangement of 4'-hydroxy-2-methoxy-4-prenyloxychalkone (III) using acetic anhydride in dimethylaniline yields four compounds, viz. 4'-acetoxy-2-methoxy-4'',4'',5''-trimethyldihydrofuranochalkone (IV), 4,4'-diacetoxy-2-methoxy-5-(α,α-dimethylallyl)chalkone (V), 4,4'-diacetoxy-2-methoxy-3-(α,α-dimethylallyl)chalkone (VI) and 4,4'-diacetoxy-2-methoxychalkone (VII).Mild alkaline hydrolysis of V affords 4,4'-dihydroxy-2-methoxy-5-(α,α-dimethylallyl)chalkone (VIII, licochalkone-A).