73600-37-0Relevant academic research and scientific papers
Electrochemical C(sp 3)-H Fluorination
Baran, Phil S.,Chen, Longrui,Chen, Miao,Hoshikawa, Tamaki,Kawamata, Yu,Li, Chao,Mykhailiuk, Pavel,Nakamura, Hugh,Peters, Byron K.,Reisberg, Solomon H.,Shibuguchi, Tomoyuki,Takahira, Yusuke
, p. 1178 - 1182 (2019)
A simple and robust method for electrochemical alkyl C-H fluorination is presented. Using a simple nitrate additive, a widely available fluorine source (Selectfluor), and carbon-based electrodes, a wide variety of activated and unactivated C-H bonds are converted into their C-F congeners. The scalability of the reaction is also demonstrated with a 100 gram preparation of fluorovaline.
