73604-30-5 Usage
Uses
Used in Neuroscience Research:
(-)-Bicuculline methobromide is used as a research tool for studying the role of GABAergic neurotransmission in various neurological processes. It helps researchers understand the mechanisms underlying epilepsy, anxiety, and other neurological disorders by blocking the inhibitory action of GABA, thus allowing for the investigation of the effects of increased neuronal activity.
Used in Pharmacological Studies:
(-)-Bicuculline methobromide is used as a pharmacological agent to investigate the interactions between GABAA receptors and other neurotransmitter systems. It is particularly useful in studying the effects of drugs that target GABAergic pathways, such as benzodiazepines, barbiturates, and neurosteroids, which modulate the activity of GABAA receptors.
Used in Drug Development:
(-)-Bicuculline methobromide is used as a lead compound in the development of new drugs targeting GABAA receptors. Its potent and selective antagonistic activity makes it a valuable starting point for the design of novel therapeutic agents for the treatment of neurological and psychiatric disorders, such as epilepsy, anxiety, and depression.
Used in Neurophysiology:
(-)-Bicuculline methobromide is used as a neurophysiological tool to study the effects of GABAergic inhibition on neuronal firing patterns and network oscillations. By blocking GABAA receptors, it allows researchers to examine the role of GABAergic signaling in the generation and modulation of brain rhythms, such as sleep spindles, theta waves, and gamma oscillations.
Biological Activity
Methobromide salt of (+)-bicuculline ([R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one ). Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.
Check Digit Verification of cas no
The CAS Registry Mumber 73604-30-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,6,0 and 4 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 73604-30:
(7*7)+(6*3)+(5*6)+(4*0)+(3*4)+(2*3)+(1*0)=115
115 % 10 = 5
So 73604-30-5 is a valid CAS Registry Number.
InChI:InChI=1/C21H20NO6.BrH/c1-22(2)6-5-11-7-15-16(26-9-25-15)8-13(11)18(22)17-12-3-4-14-20(27-10-24-14)19(12)28-21(17)23;/h3-4,7-8,17-18H,5-6,9-10H2,1-2H3;1H/q+1;/p-1/t17-,18+;/m1./s1
