736142-69-1Relevant academic research and scientific papers
Identification of new arylsulfide derivatives as anti-melanogenic agents in a zebrafish model
Ahn, Jin Hee,Ahn, Se Hwan,Bae, Eun Jung,Bae, Myung Ae,Choi, Byeong Wook,Hwang, Kyu-Seok,Kim, Seong Soon,Lee, Byung Hoi,Shin, Dae-Seop,Yang, Jung Yoon
, (2020)
A series of aryl sulfide derivatives was synthesized and evaluated for their anti-melanogenic activities. Several compounds, including 3e, 3i and 3q exhibited good anti-melanogenic activities. Among the derivatives, compound 3i showed good inhibitory effe
Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors
Laufer, Stefan A.,Domeyer, David M.,Scior, Thomas R. F.,Albrecht, Wolfgang,Hauser, Dominik R. J.
, p. 710 - 722 (2007/10/03)
On the basis of ATP adenine, a series of adenine and purine derivatives was prepared and tested for their ability to inhibit a spectrum of disease-related kinases. There has been scant research investigating the potential of cosubstrate derived kinase inhibitors for other kinases than CDKs. Our inhibitor design combined the purine system from the original cosubstrate ATP and phenyl moieties in order to explore possible interactions with the different regions of the ATP binding site in several disease-related protein kinases. There have been a number of hits for the assayed substances, which led us to conclude that the spectrum of compounds may prove to be a valuable tool kit for the evaluation of bonding and selectivity patterns for a wide variety of kinases.
