736142-76-0Relevant academic research and scientific papers
Synthesis and biological evaluation of purine derivatives incorporating metal chelating ligands as HIV integrase inhibitors
Li, Xingnan,Vince, Robert
, p. 5742 - 5755 (2007/10/03)
Because of its essential role in HIV replication and lack of human counterpart, HIV integrase is an attractive target for the development of novel anti-AIDS agents. Among the recently developed integrase inhibitors, only the α,γ-diketo acid (DKA) compound
Synthesis, biological activity, and SAR of antimycobacterial 9-aryl-, 9-arylsulfonyl-, and 9-benzyl-6-(2-furyl)purines
Bakkestuen, Anne Kristin,Gundersen, Lise-Lotte,Utenova, Bibigul T.
, p. 2710 - 2723 (2007/10/03)
9-Aryl-, 9-arylsulfonyl- and 9-benzyl-6-(2-furyl)purines were synthesized by N-alkylation or N-arylation of the purine followed by Stille coupling to introduce the furyl substituent in the 6-position and the compounds screened for activity against Mycobac
