736173-17-4

Basic information

• Product Name: 2-[AMINO-(4-CHLORO-PHENYL)-METHYL]-NAPHTHALEN-1-OL HYDROCHLORIDE
• Synonyms: 2-[AMINO-(4-CHLORO-PHENYL)-METHYL]-NAPHTHALEN-1-OL HYDROCHLORIDE
• CAS NO: 736173-17-4
• Molecular Formula: C17H15Cl2NO
• Molecular Weight: 320.21
• Mol File: 736173-17-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 167-169 °C(Solv: methanol (67-56-1); ethyl ether (60-29-7))
• Boiling Point: 503.8°C at 760 mmHg
• Flash Point: 258.5°C
• Appearance: /
• Vapor Pressure: 9.02E-11mmHg at 25°C
• CAS DataBase Reference: 2-[AMINO-(4-CHLORO-PHENYL)-METHYL]-NAPHTHALEN-1-OL HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[AMINO-(4-CHLORO-PHENYL)-METHYL]-NAPHTHALEN-1-OL HYDROCHLORIDE(736173-17-4)
• EPA Substance Registry System: 2-[AMINO-(4-CHLORO-PHENYL)-METHYL]-NAPHTHALEN-1-OL HYDROCHLORIDE(736173-17-4)

Safety Data

• Hazardous Substances Data: 736173-17-4(Hazardous Substances Data)

Usage

Chemical compound

2-[Amino-(4-chloro-phenyl)-methyl]-naphthalen-1-ol hydrochloride

Structure

Consists of a naphthalene ring with an amino group attached to the carbon atom, a 4-chloro-phenyl group, and a hydroxyl group

Form

Hydrochloride salt

Uses

Potential applications in pharmaceutical and chemical research, development of new drugs, reagent in organic synthesis, medicinal chemistry for the design of bioactive compounds

InChI:InChI=1/C17H14ClNO.ClH/c18-13-8-5-12(6-9-13)16(19)15-10-7-11-3-1-2-4-14(11)17(15)20;/h1-10,16,20H,19H2;1H

Upstream product

• 90-15-3 α-naphthol 

Relevant articles and documents

Synthesis of 2,4-diaryl-3,4-dihydro-2H-naphth[2,1-e][1,3]oxazines and study of the effects of the substituents on their ring-chain tautomerism

A number of 2-(α-amino-Y-substituted-benzyl)-1-naphthol hydrochlorides were prepared by a convenient Mannich-type aminoalkylation. 2,4-Diaryl-3,4-dihydro-2H-naphth-[2,1-e][1,3]oxazines were prepared through the ring-closure reactions of the starting aminonaphthols with aromatic aldehydes, which proved to furnish three-component (ring1-open-ring2) tautomeric mixtures in CDCl3 at 300 K. The electronic effects of the 2-aryl groups on the ratios of the ring-chain tautomeric forms at equilibrium could be described by Equation (1). Study of the effects of substituents X and Y on the tautomeric equilibria [by the aid of the multiple linear regression analysis of Equations (2) and (3)] revealed that the trans-chain equilibrium constants are significantly influenced by the inductive effect (σF) of substituent Y on the 4-phenyl ring. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.