736173-20-9

Basic information

• Product Name: 2-[AMINO-(4-METHOXY-PHENYL)-METHYL]-NAPHTHALEN-1-OL HYDROCHLORIDE
• Synonyms: 2-[AMINO-(4-METHOXY-PHENYL)-METHYL]-NAPHTHALEN-1-OL HYDROCHLORIDE
• CAS NO: 736173-20-9
• Molecular Formula: C18H18ClNO2
• Molecular Weight: 315.79
• Mol File: 736173-20-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 512.2°C at 760 mmHg
• Flash Point: 263.5°C
• Appearance: /
• Vapor Pressure: 4.13E-11mmHg at 25°C
• CAS DataBase Reference: 2-[AMINO-(4-METHOXY-PHENYL)-METHYL]-NAPHTHALEN-1-OL HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[AMINO-(4-METHOXY-PHENYL)-METHYL]-NAPHTHALEN-1-OL HYDROCHLORIDE(736173-20-9)
• EPA Substance Registry System: 2-[AMINO-(4-METHOXY-PHENYL)-METHYL]-NAPHTHALEN-1-OL HYDROCHLORIDE(736173-20-9)

Safety Data

• Hazardous Substances Data: 736173-20-9(Hazardous Substances Data)

Usage

Chemical structure

2-[amino-(4-methoxy-phenyl)-methyl]-naphthalen-1-ol hydrochloride

Properties

hydrochloride salt form, contains an amino group and a methoxyphenylmethyl group

Use

pharmaceutical research and development, potential drug candidate

Therapeutic applications

potential treatment of various medical conditions

Biological impact

ability to interact with biological systems and impact biological processes

Further research needed

to fully understand pharmacological properties and potential uses

InChI:InChI=1/C18H17NO2.ClH/c1-21-14-9-6-13(7-10-14)17(19)16-11-8-12-4-2-3-5-15(12)18(16)20;/h2-11,17,20H,19H2,1H3;1H

Upstream product

• 90-15-3 α-naphthol 

Relevant articles and documents

Synthesis of 2,4-diaryl-3,4-dihydro-2H-naphth[2,1-e][1,3]oxazines and study of the effects of the substituents on their ring-chain tautomerism

A number of 2-(α-amino-Y-substituted-benzyl)-1-naphthol hydrochlorides were prepared by a convenient Mannich-type aminoalkylation. 2,4-Diaryl-3,4-dihydro-2H-naphth-[2,1-e][1,3]oxazines were prepared through the ring-closure reactions of the starting aminonaphthols with aromatic aldehydes, which proved to furnish three-component (ring1-open-ring2) tautomeric mixtures in CDCl3 at 300 K. The electronic effects of the 2-aryl groups on the ratios of the ring-chain tautomeric forms at equilibrium could be described by Equation (1). Study of the effects of substituents X and Y on the tautomeric equilibria [by the aid of the multiple linear regression analysis of Equations (2) and (3)] revealed that the trans-chain equilibrium constants are significantly influenced by the inductive effect (σF) of substituent Y on the 4-phenyl ring. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.