736181-82-1Relevant academic research and scientific papers
From virtual to clinical: The discovery of PGN-1531, a novel antagonist of the prostanoid EP4 receptor
Sutton, Jon,Clark, David E.,Higgs, Christopher,De Groot, Marcel J.,Harris, Neil V.,Taylor, Andrea,Lockey, Peter M.,Maubach, Karen,Woodrooffe, Amanda,Davis, Richard J.,Coleman, Robert A.,Clark, Kenneth L.
, p. 2212 - 2221 (2014/05/06)
In this Letter, we present the results of a hit-finding and lead optimization programme against the EP4 receptor (EP4R). In a short time period, we were able to discover five structurally diverse series of hit compounds using a combi
EP4 RECEPTOR ANTAGONISTS
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Page 57; 58, (2008/06/13)
Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either -(CH2)n-X-, where n is 1 or 2 and X is O, S, S(=O), S(=O)2, or NRN1, where RN/sup
