73631-29-5

Upstream product

• 73631-17-1 N^α-cyano-3,5-diamino-6-chloropyrazine-2-carboxamide hydrochloride 
• 32205-65-5 3,5-diamino-6-chloro-N-<(hydroxyimino)aminomethylene>pyrazine-2-carboxamide 
• 73631-28-4 3,5-Diamino-6-chloro-pyrazine-2-carboximidic acid ethyl ester; hydrochloride 
• 17231-59-3 3,5-diamino-6-chloro-2-pyrazinecarbonitrile 
• 1458-01-1 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

The colour reaction of amiloride hydrochloride ph. eur.

The reaction of amiloride hydrochloride (1.HCI) with bromine in alkaline solution generated a yellow-brown dehydrogenation product, which turned out as 3-(3-amino-1,2,4-oxadiazol-5-yl)-5-chloro-2,6-pyrazinediamine (2). The structure was deduced from the MS and the NMR spectra of 2 with the help of comparisons with corresponding spectra of amiloride (1) and reference substances 3 - 5. The agreement of all relevant data of the product and of authentical oxadiazolylpyrazine 2 as well as the accomplished X-ray analysis confirmed the postulated structure. The mechanism of the formation of 2 is also discussed.

Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA)

A known side-activity of the oral potassium-sparing diuretic drug amiloride is inhibition of the enzyme urokinase-type plasminogen activator (uPA, K i = 7 μM), a promising anticancer target. Several studies have demonstrated significant antitum

Substituted pyrazinyl-1,2,4-oxadiazoles

Novel substituted pyrazinyl-1,2,4-oxadiazoles and processes for preparing the same. The compounds are useful in the treatment of edema and hypertension.

Method of treating edema and hypertension and pharmaceutical composition therefor in which the active ingredient comprises a novel substituted pyrazinyl-1,2,4-oxadiazole and a kaliuretic diuretic

Novel pyrazinyl -1,2,4-oxadiazoles of the formulas: STR1 are useful in treating edema and hypertension, and particularly may be combined with kaliuretic diuretics such as hydrochlorothiazide and indacrinone.

Synthesis and Diuretic Profile of 3-(3-Amino-1,2,4-oxadiazol-5-yl)-5-chloro-2,6-pyrazinediamine, an Amiloride-Type Diuretic

The synthesis of an analogue of amiloride in which the acylguanidine moiety has been replaced by a 1,2,4-oxadiazol-3-amine unit is described.This substance (3, CGS 4270) exhibited a diuretic profile similar to that of amiloride when evaluated in the rat a