73644-95-8

Usage

Uses

Used in Organic Synthesis:
3-Methyl-1,3,4,5-tetrahydrobenzo[d]azepin-2-one is used as a key intermediate in organic synthesis for the creation of various chemical entities. Its unique structure allows it to serve as a building block for the synthesis of complex organic molecules, contributing to the advancement of chemical research and development.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 3-Methyl-1,3,4,5-tetrahydrobenzo[d]azepin-2-one is utilized as a starting material for the development of new drugs. Its potential pharmacological properties make it a valuable candidate for the discovery of novel therapeutic agents, particularly those targeting specific biological pathways or diseases.
Used in the Synthesis of Biologically Active Compounds:
3-Methyl-1,3,4,5-tetrahydrobenzo[d]azepin-2-one is employed as a precursor in the synthesis of biologically active compounds. Its incorporation into these compounds can enhance their efficacy, selectivity, and pharmacokinetic properties, leading to the development of more effective treatments for various medical conditions.

InChI:InChI=1S/C11H13NO/c1-12-7-6-9-4-2-3-5-10(9)8-11(12)13/h2-5H,6-8H2,1H3

Upstream product

• 15987-50-5 1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one 
• 74-88-4 methyl iodide 
• 117034-52-3 9-Hydroxy-3-methyl-3-aza-spiro[5.5]undeca-7,10-dien-2-one 
• 13156-97-3 2-chloro-N-phenylethylpropanamide 
• 589-08-2 N-Methyl-N-phenethylamine 
• 103-63-9 1-phenyl-2-bromoethane 
• 13230-84-7 2-chloro-N-methyl-N-(2-phenylethyl)acetamide 

Downstream Products

• 73645-05-3 1,2,4,5-tetrahydro-1-cyclohexyl-3-methyl-3H-3-benzazepin-2-one 
• 1428449-34-6 4,5-dihydro-3-methyl-1-(2-tolyl)-1H-benzo[d]azepin-2(3H)-one 
• 1428449-35-7 4,5-dihydro-3-methyl-1-(4-tolyl)-1H-benzo[d]azepin-2(3H)-one 
• 1428449-36-8 1-(3-fluorophenyl)-4,5-dihydro-3-methyl-1H-benzo[d]azepin-2(3H)-one 
• 1428449-37-9 1-(4-fluorophenyl)-4,5-dihydro-3-methyl-1H-benzo[d]azepin-2(3H)-one 
• 1428449-38-0 4,5-dihydro-3-methyl-1-(3,5-dimethylphenyl)-1H-benzo[d]azepin-2(3H)-one 
• 1428449-40-4 1-(4-ethylphenyl)-4,5-dihydro-3-methyl-1H-benzo[d]azepin-2(3H)-one 
• 1428449-41-5 1-(1,1'-biphenyl-4-yl)-4,5-dihydro-3-methyl-1H-benzo[d]azepin-2(3H)-one 
• 1428449-29-9 4,5-dihydro-1-(3-methoxyphenyl)-3-methyl-1H-benzo[d]azepin-2(3H)-one 
• 1428449-30-2 4,5-dihydro-3-methyl-1-(3-tolyl)-1H-benzo[d]azepin-2(3H)-one 
• 1428449-31-3 1-(3-(trifluoromethyl)phenyl)-4,5-dihydro-3-methyl-1H-benzo[d]azepin-2(3H)-one 
• 1428449-32-4 4,5-dihydro-1-(4-methoxyphenyl)-3-methyl-1H-benzo[d]azepin-2(3H)-one 
• 1428449-33-5 4,5-dihydro-1-(2-methoxyphenyl)-3-methyl-1H-benzo[d]azepin-2(3H)-one 
• 425386-58-9 (1S)-1-amino-3-methyl-1H,4H,5H-benzo[d]azaperhydroepin-2-one di-p-toluoyl-L-tartrate 

Relevant academic research and scientific papers

SUBSTITUTED PROLINAMIDES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS

The present invention provides new substituted prolinamides of the general formula (I) in which D, L, E, G, J, M, R3, R4, R5, and R13 are defined as in claim 1, their tautomers, their enantiomers, their diastere

Classical and dynamic resolution of 1-amino-3-methyl-1,3,4,5- tetrahydrobenzo[d]azepin-2-one

Two efficient production processes of enantioenriched 1-amino-3-methyl-1,3, 4,5-tetrahydro-benzo[d]azepin-2-one 1 were achieved using the readily available starting materials. A key step in the methodologies is a classical resolution or a dynamic resolution that provides excellent chemical (>80%) yields and enantiomeric excesses (>99.8% ee). The classical resolution was developed on a preparative scale while the dynamic resolution was implemented on a pilot plant scale.

SYNTHESIS OF 5-HYDROXY-3-TRIFLUOROMETHYL-PYRAZOLES BY RING OPENING OF 3-TRIFLUOROACETYL-BENZOLACTAMS

New trifluoromethylated pyrazoles 5b,c,f have been prepared by condensation of 3-trifluoroacetyl benzolactams 1a,b,c and 2 with hydrazines by opening of the lactam moiety.The structure of pyrazoles was established by X-ray diffraction analysis and by comp

ACID-CATALYZED CYCLIZATIONS OF AROMATIC DIAZOACETAMIDES: SYNTHESIS OF SPIRODIENONE LACTAMS, ISOQUINOLINES, AND BENZAZEPINONES

Acid-catalyzed cyclizations of aromatic diazoacetamides produce good yields of simple isoquinolinones and benzazepinones.The intermediacy of spirodienone oxonium species has been demonstrated by trapping and isolation of synthetically useful spirodienone

BENZOLACTAMS-1. ALKYLATION OF 1,2,4,5-TETRAHYDRO-3-METHYL-3H-3-BENZAZEPIN-2-ONE WITH SODIUM HYDRIDE AND ALKYL HALIDE

Alkylation of 1,2,4,5-tetrahydro-3-methyl-3H-3-benzazepin-2-one 1a with various halides and sodium hydride in tetrahydrofuran-dimethylformamide solvent system was studied.Primary halides predominantly provided the 1-mono-substituted products, such as alkyl (2a-g,p,q), allyl (2j,k), propargyl (2l) and benzyl (2m-o) derivatives, in satisfactory yields, and secondary halides resulted in lower yields (2h,i) than primary halides.In attempted dialkylations with ω,ω'-dibromoalkanes, 5- and 6-membered spiro products (4c,d) were obtained by this method.The Michael type addition reaction was also studied and it was found that acrylic acid esters gave the corresponding adducts (2p,q).