7365-82-4

Basic information

• Product Name: N-(Carbamoylmethyl)taurine
• Synonyms: N-(2-ACETAMIDO)-2-AMINOETHANESULFONIC ACID;N-(2-ACETAMIDO)-2-AMINOETHANESULPHONIC ACID;N-(CARBAMOYLMETHYL)TAURINE;N-(CARBAMOYLMETHYL)-2-AMINOETHANESULFONIC ACID;TIMTEC-BB SBB006711;ACES;ACES BUFFER;2-(CARBAMOYLMETHYLAMINO)ETHANESULFONIC ACID
• CAS NO: 7365-82-4
• Molecular Formula: C₄H₁₀N₂O₄S
• Molecular Weight: 182.2
• EINECS: 230-908-4
• Product Categories: Biochemistry;Good's Buffers;Buffer
• Mol File: 7365-82-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: >220 °C (dec.)(lit.)
• Boiling Point: 404.49℃
• Appearance: White/Crystals
• Density: 1.484 g/cm³
• Vapor Pressure: 0Pa at 25℃
• Refractive Index: 1.536
• Storage Temp.: Store at RT.
• Solubility: H2O: 0.1 M at 20 °C, clear, colorless
• PKA: 6.8(at 25℃)
• Water Solubility: soluble
• Merck: 14,36
• BRN: 2253770
• CAS DataBase Reference: N-(Carbamoylmethyl)taurine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(Carbamoylmethyl)taurine(7365-82-4)
• EPA Substance Registry System: N-(Carbamoylmethyl)taurine(7365-82-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-24/25
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 7365-82-4(Hazardous Substances Data)

Usage

Chemical Properties

N-(Carbamoylmethyl)taurine is white crystals

Uses

Different sources of media describe the Uses of 7365-82-4 differently. You can refer to the following data:
1. N-(Carbamoylmethyl)taurine can be used to study biological buffers and zwitterionic compounds. ACES has been used in a study to determine the levels of ibuprofen and flurbiprofen in pharmaceuticals by capillary zone electrophoresis.
2. Buffer for biological systems.
3. ACES is used as a Good's buffer is an ideal separator in the resolution of protein systems, a zwitterionic compound used in biochemical and biological research.

Purification Methods

Recrystallise ACES from hot aqueous EtOH. [Perrin & Dempsey Buffers for pH and Metal Ion Control Chapman & Hall, London 1974, Beilstein 4 III 1707.]

InChI:InChI=1/C4H10N2O4S/c5-4(7)3-6-1-2-11(8,9)10/h6H,1-3H2,(H2,5,7)(H,8,9,10)

Synthetic route

C4H9NO5S → N-(2-acetamido)-2-aminoethanesulfonic acid (7365-82-4)

Conditions	Yield
With ammonia In tetrahydrofuran at 60℃; under 7500.75 Torr; for 8h;	82%

C5H11NO5S → N-(2-acetamido)-2-aminoethanesulfonic acid (7365-82-4)

Conditions	Yield
With ammonia In tetrahydrofuran at 60℃; under 3750.38 Torr; for 8h;	82%

N-(ethyl acetate)-2-aminoethanesulfonic acid → N-(2-acetamido)-2-aminoethanesulfonic acid (7365-82-4)

Conditions	Yield
With ammonia In acetonitrile at 60℃; under 3750.38 Torr; for 8h;	80%

Relevant articles and documents

Preparation process of N-(2-acetamido)-2-aminoethanesulfonic acid

The invention discloses a preparation process of N-(2-acetamido)-2-aminoethanesulfonic acid. The preparation process comprises the following steps: subjecting a compound 1 with a structure as shown inthe specification to reacting with a compound 2 with a structure as shown in the specification so as to obtain a first intermediate product with a structure as shown in the specification; subjectingthe first intermediate product to reacting with at least one of a sulfur-containing reagent and an oxidation reagent to obtain a second intermediate product with a structure shown in the specificationor a salt thereof; and subjecting the second intermediate product or the salt thereof to reacting with a nitrogen-containing reagent to obtain N-(2-acetamido)-2-aminoethanesulfonic acid. In the formulas of the invention, A and X are respectively one selected from the group consisting of halogen, OH, SH and NH2, and at least one of A and X is NH2; Y is one selected from the group consisting of halogen, OH and SH; and Z is one selected from the group consisting of OH, OR, OM, SH and SR. The process has the advantages that the price of initial raw materials and production cost are low; reactionconditions are mild; purification process is simple; the yield of N-(2-acetamido)-2-aminoethanesulfonic acid is high; and the whole preparation process is simple, easy to control and beneficial for large-scale production.

Isolation of nucleic acids

A method for extracting nucleic acids from a biological material such as blood comprises contacting the mixture with a material at a pH such that the material is positively charged and will bind negatively charged nucleic acids and then eluting the nucleic acids at a pH when the said materials possess a neutral or negative charge to release the nucleic acids. The nucleic acids can be removed under mildly alkaline conditions to the maintain integrity of the nucleic acids and to allow retrieval of the nucleic acids in reagents that are immediately compatible with either storage or analytical testing.

Zwitterionic compounds and their n-halo derivatives for use in the treatment of clinical conditions

Zwitterionic compounds selected from: taurine (2-aminoethanesulphonic acid), 2(N-morpholino)ethanesulphonic acid (MES), N-(2-acetamido)iminodiacetic acid (ADA), piperazine-N,N'bis(2-ethanesulphonic acid (PIPES), N-(2-acetamido)-2-aminoethanesulphonic acid (ACES), N,N-bis(2-hydroxyethyl)-2-aminoethanesulphonic acid (BES), 3-(N-morpholino)propanesulphonic (MOPS), N-N[tris(hydroxymethyl)-methyl]-2-aminoethanesulphonic acid (TES), N-2-hydroxyethylpiperazine-N'-2-ethanesulphonic acid (HEPES), N-2-hydroxyethylpiperazine-N'3-propanesulphonic acid (H)EPPS), 2-(cyclohexylamino)ethanesulphonic acid (CHES) or 3-(cyclohexylamino)propanesulphonic acid (CAPS), and their N-halo derivatives can be used separately or in combination in the treatment of related clinical conditions by stimulating myeloperoxidase activity, which in turn stimulates hypochlorous acid production in vivo, which leads inter alia to enhanced leukotriene inactivation.