73650-41-6

Upstream product

• 856410-04-3 1-ethyl 4-methyl 2-trichloroacetylamino-3-methylidenebutanedioate 
• 30313-07-6 diethyl 2-ethoxycarbonyl-3-methylbutadienoate 
• 71195-11-4 triethyl prop-2-ene-1,1,2-tricarboxylate 
• 108735-94-0 1-Ethyl 4-methyl 2-hydroxy 3-methylenebutanedioate 
• 856410-03-2 1-ethyl 4-methyl 2-trichloroacetylaminocarbonyloxy-3-methylenebutandioate 
• 856410-05-4 1-ethyl 4-methyl 2-trichloroacetiminoxy-3-methylidenebutanedioate 
• 71195-13-6 1-Amino-1,1,2-tricarbethoxy-prop-2-en 

Relevant academic research and scientific papers

Straightforward synthesis of (R,S)-β-methyleneaspartic acid, an inhibitor of glutamate-aspartate transaminase

A Baylis-Hillman adduct of methyl acrylate and ethyl glyoxalate was converted into the trichloroacetimidate that in the presence of DABCO rearranged to the corresponding trichloroacetamide. Eventually, hydrolysis under acidic conditions, led to the hydrochloride of racemic β-methyleneaspartic acid. Springer-Verlag 2006.

Artificial Glutamate Mutase Composed of Hydrophobic Vitamin B12 and Synthetic Bilayer Membrane

The alkylated hydrophobic vitamin B12, prepared by the reaction between heptapropyl cobyrinate and diethyl bromomethylasparate, afforded diethyl glutamate, the rearrangement product, in single-compartment vesicles under anaerobic photolysis conditions.