73652-97-8Relevant academic research and scientific papers
Synthesis, structure and pharmacological activity of acyl-2-naphthalene acetic acids and derivatives
Saint Martino Descours,Pacheco,Venco,Yavordios
, p. 5 - 9 (2007/10/02)
Acyl 2-naphthalene acetic derivatives are obtained by a Friedel and Crafts reaction from methyl 2-naphthalene acetate. Low polarity solvents permit selective acylation in the 5 and 8 position, polar solvents in position 6 and 7. The structure of these products is demonstrated by NMR spectra (250 MHz) studies. Unambiguous syntheses of several of them were performed. Acyl 2-naphthalene acetic derivatives show lower anti-inflammatory, analgesic and antipyretic activities in animals than their 1-naphthalene analogs.
