73674-38-1

Upstream product

• 77857-64-8 (2S)-(-)-(N-cyclodecylidine)-1-methoxy-3-phenyl-2-propylamine 
• 74-88-4 methyl iodide 

Downstream Products

• 130409-65-3 (Z)-1-(benzoyloxy)-2-methylcyclodecene 
• 73674-41-6 2-Methyl-cyclodecanon-(2,4-dinitrophenylhydrazon) 

Relevant academic research and scientific papers

Oxidation catalytic system and oxidation process using the same

A substrate (e.g., a cycloalkane, a polycyclic hydrocarbon, an aromatic compound having a methyl group or methylene group adjacent to an aromatic ring) is oxidized with oxygen in the presence of an oxidation catalyst comprising an imide compound of the following formula (1) (e.g., N-hydroxyphthalimide), and a co-catalyst (except phosphovanadomolybdic acid) containing an element selected from the group consisting of Group 2A elements of the Periodic Table of Elements, transition metals (Group 3A to 7A elements, Group 8 elements, Group 1B elements and Group 2B elements of the Periodic Table of Elements) and Group 3B elements of the Periodic Table of Elements, for the formation of an oxide (e.g., a ketone, an alcohol, a carboxylic acid): STR1 wherein R1 and R2 represent a substituent such as a hydrogen atom or a halogen atom, or R1 and R2 may together form a double bond or an aromatic or nonaromatic 5- to 12-membered ring, X is O or OH, and n is 1 to 3.

An Asymmetric Synthesis of Acyclic and Macrocyclic α-Alkyl Ketones. The Role of (E)- and (Z)-Lithioenamines

Metalation and alkylation of chiral imines derived from C10, C12, and C15 cyclic ketones gave, under kinetic metalation conditions, 2-alkylcycloalkanones of absolute configuration opposite to that formed from thermodynamic metalation.Thus, (S)-(-)-2-methylcyclododecanone is formed kinetically in 60percent ee, whereas (R)-(+)-methylcyclododecanone is reached in 80percent ee under thermodynamic conditions.In a similar fashion, acyclic ketones 20, via their chiral imines 17, are alkylated enantioselectively under both kinetic and thermodynamic modes.The kinetic metalation gives exclusively the (Z)-lithioenamines (19), while reflux of this lithio anion gives only the (E)-lithioenamine (19).Chiral α-substituted ketones are produced in 18-97percent ee.