7369-27-9

Upstream product

• 50-00-0 formaldehyd 
• 112429-68-2 2,3-bis(acetoxymethyl)phenyl acetate 
• 37418-88-5 3-hydroxyphthalic anhydride 

Downstream Products

• 112429-70-6 (2,2-dimethyl-4H-benzo[d][1,3]dioxin-5-yl)methanol 
• 88557-39-5 Acetic acid (1R,2S)-2-acetoxy-1-[(E)-2-(3-hydroxy-2-hydroxymethyl-phenyl)-vinyl]-heptyl ester 
• 88557-40-8 dechloromonilidiol diacetate 
• 85414-35-3 dechloromonilidiol 

Relevant academic research and scientific papers

Oxidative dearomatization and unusual intramolecular Diels-Alder reaction of cyclohexa-2,4-dienone: Synthesis and photoreaction of oxa-tricyclo[5.2.2.01,5]undec-10-ene-8-ones

Abstract An efficient synthesis of annulated bicyclo[2.2.2]octane having β,γ-enone chromophoric system and triplet sensitized 1,2-acyl shift rearrangement leading to the formation of angular oxa-triquinane is described. Oxidative dearomatization, intramolecular Diels-Alder reaction of 6,6-spiroepoxycyclohexa-2,4-dienone and oxa-di-π-methane reaction are the key features of our approach.

Synthesis and preliminary biological evaluation of new antiproliferative aromatic analogues of 1α,25-dihydroxyvitamin D3

In an effort to develop novel vitamin D3 analogues, a series of aromatic compounds was synthetized, using efficient Negishi cross coupling between alkenylzinc reagents of the C,D-ring moiety of vitamin D3, and various substituted aromatic halides as A-ring mimics. The study aimed at exploring the influence of the replacement of the original vitamin D3 diene by a styrene unit on the biological activities. Potency in the induction of the differentiation of HL-60 cells for the lead compound 36 was 12 fold less important than calcitriol correlating with a weaker binding affinity for VDR.

Aryl carboxylic acid and aryl tetrazole derivatives as IP receptor modulators

This invention relates to compounds which are generally IP receptor modulators, particularly IP receptor agonists, and which are represented by Formula I: wherein R1, R2, R3, R4, R5, A, and B are as defined in the specification, and individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.

Synthesis and Absolute Configuration of Pyriculol

A total synthesis of optically active pyriculol is described.The Wittig reaction between an aldehyde 19 and a triphenylphosphonium ylide 12 gave an intermediate 20.Successive treatment of 20 with p-toluenesulfonic acid, active manganese dioxide, and potassium carbonate gave (3'R,4'S)-pyriculol (23), which was identical with natural pyriculol (1) in all respects.From this synthesis the absolute stereochemistry of pyriculol (1) was determined to be 2--6-hydroxybenzaldehyde.