736971-53-2

Upstream product

• 5922-04-3 2-(2,6-Dichloro-phenyl)-acetimidic acid methyl ester 
• 5922-20-3 2-(2,6-dichlorophenyl)-1-methoxyethanimine hydrochloride 
• 6059-44-5 methyl 2,3-diaminopropanoate dihydrochloride 

Downstream Products

• 736971-55-4 methyl 2-[(2,6-dichlorophenyl)methyl]imidazole-5-carboxylate 
• 736971-48-5 2-(2,6-dichloro-benzyl)-1H-imidazole-4-carboxylic acid (4-trifluoromethyl-phenyl)-amide 
• 748769-95-1 2-(2,6-dichloro-benzyl)-1H-imidazole-4-carboxylic acid 
• 736971-55-4 2-(2,6-dichloro-benzyl)-1H-imidazole-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Synthesis and evaluation of thiazole carboxamides as vanilloid receptor 1 (TRPV1) antagonists

A thiazole derivative, 2-(2,6-dichlorobenzyl)-N-(4-isopropylphenyl) thiazole-4-carboxamide (1), was identified as a TRPV1 antagonist. We synthesized various thiazole analogs and evaluated them for their ability to block capsaicin- or acid-induced calcium influx in TRPV1-expressing CHO cells. The IC50 values of the most potent antagonists were ca. 0.050 μM in these assays.

Vanilloid receptor ligands and their use in treatments

Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.