736982-09-5Relevant academic research and scientific papers
Thiourea inhibitors of herpesviruses. Part 3: Inhibitors of varicella zoster virus
Di Grandi, Martin J.,Curran, Kevin J.,Feigelson, Gregg,Prashad, Amar,Ross, Adma A.,Visalli, Robert,Fairhurst, Jeanette,Feld, Boris,Bloom, Jonathan D.
, p. 4157 - 4160 (2007/10/03)
The preparation of α-methylbenzyl thioureas and their biological activity against varicella zoster virus is described. Several analogs demonstrated IC50s0.1μM and their SAR are discussed. These compounds represent a novel class of potent and selective nonnucleoside inhibitors of varicella zoster virus.
Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus
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Page 5, (2008/06/13)
This Invention provides a compound of the Formula: wherein X is R1, R2, R3 and R4 are described in the specification and a pharmaceutical composition comprising the compound used for inhibiting replication of a
