736990-80-0

Basic information

• Product Name: 4-BROMO-2-(N-MORPHOLINO)-BENZALDEHYDE
• Synonyms: 4-BROMO-2-(N-MORPHOLINO)-BENZALDEHYDE;4-broMo-2-(Morpholin-4-yl)benzaldehyde;4-BroMo-2-Morpholinobenzaldehyde
• CAS NO: 736990-80-0
• Molecular Formula: C₁₁H₁₂BrNO₂
• Molecular Weight: 270.12
• Mol File: 736990-80-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-BROMO-2-(N-MORPHOLINO)-BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-(N-MORPHOLINO)-BENZALDEHYDE(736990-80-0)
• EPA Substance Registry System: 4-BROMO-2-(N-MORPHOLINO)-BENZALDEHYDE(736990-80-0)

Safety Data

• Hazardous Substances Data: 736990-80-0(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-(N-morpholino)-benzaldehyde is a versatile and useful chemical compound with several applications in the field of chemistry, particularly in organic synthesis. It serves as an important intermediate in the preparation of other compounds, particularly drugs and pharmaceuticals. As evident from its name, this chemical is characterized by the presence of a bromine (Br) atom, a morpholino group, and a benzaldehyde moiety in its structure. The detailed properties of this compound such as its density, melting point, boiling point, molecular weight, etc. would be specific to its particular formulation. It should be noted that all safety and handling procedures must be adhered to while working with this compound, as it may exhibit specific physical or health hazards.

Upstream product

• 110-91-8 morpholine 
• 57848-46-1 4-bromo-2-fluorobenzaldehyde 

Downstream Products

• 1285507-38-1 C₁₆H₂₀BrNO₃ 
• 1285506-93-5 C₁₄H₁₆BrNO₃ 
• 1285506-96-8 C₁₅H₁₉BrN₄O₂ 
• 1285505-69-2 N-[(E)-3-(4'-hydroxy-3-morpholine-4-yl-biphenyl-4-yl)-2-methyl-acryloyl]-guanidine 
• 197846-82-5 1-(3-bromophenyl)-morpholine 

Relevant articles and documents

Catalyst-free photodecarbonylation ofortho-amino benzaldehyde

It is almost a consensus that decarbonylation of the aldehyde group (-CHO) needs to not only be mediated by transition metal catalysts, but also requires severe reaction conditions (high temperature and long reaction time). In this work, inspired by the “conformational-selectivity-based” design strategy, we broke this consensus and discovered a catalyst-free photodecarbonylation of the aldehyde group. It revealed that decarbonylation can be easily achieved with visible light irradiation by introducing a tertiary amine into theortho-position of the aldehyde group. A diverse array of tertiary amines is tolerated by our photodecarbonylation under mild conditions. Furthermore, the (QM) computations of the mechanism and the experiments on well-designed special substrates revealed that our photodecarbonylation depends on the conformational specificity of the aldehyde group and tertiary amine, and occurs through an unusual [1,4]-H shift and a subsequent [1,3]-H shift.

Product-selectivity control by the nature of the catalyst: Lewis acid-catalyzed selective formation of ring-fused tetrahydroquinolines and tetrahydroazepines via intramolecular redox reaction

Selective synthesis of ring-fused tetrahydroquinolines and tetrahydroazepines from the same starting materials was achieved by subtle use of the oxophilic Sc(OTf)3 or carbophilic IPrAuOTf as the catalyst.