736991-26-7Relevant academic research and scientific papers
Pyrrolo-pyrimidones: A novel class of MK2 inhibitors with potent cellular activity
Schlapbach, Achim,Feifel, Roland,Hawtin, Stuart,Heng, Richard,Koch, Guido,Moebitz, Henrik,Revesz, Laszlo,Scheufler, Clemens,Velcicky, Juraj,Waelchli, Rudolf,Huppertz, Christine
scheme or table, p. 6142 - 6146 (2009/07/18)
Pyrrolo-pyrimidones of the general structure 1 were synthesized and evaluated for their potential as MK2 inhibitors. Potent derivatives were discovered which inhibit MK2 in the nanomolar range and show potent inhibition of cytokine release from LPS-stimul
