736993-15-0

Upstream product

• 1024616-67-8 5-[(1R,2S,3R,4R)-5'-(tert-butyldiphenylsilyloxy)-2',3'-O-isopropylidene-1',4'-dioxypentyl]-2,4-dimethoxypyrimidine 
• 736993-14-9 C₃₀H₄₀N₂O₇Si 

Downstream Products

• 1024616-70-3 5'-O-(tert-butyldiphenylsilyl)-2',3'-O-(isopropylidene)pseudouridine 
• 215110-22-8 5'-O-(tert-butyldiphenylsilyl)pseudouridine 

Relevant academic research and scientific papers

Synthesis and solution conformation studies of 3-substituted uridine and pseudouridine derivatives

A series of 3-substituted uridine and pseudouridine derivatives, based on the naturally occurring 3-(3-amino-3-carboxypropyl) modification, were synthesized. Their aqueous solution conformations were determined by using circular dichroism and NMR spectroscopy. Functional group composition and chain length were shown to have only a subtle influence on the distribution of syn/anti conformations of the modified nucleosides. The dominating factor appears to be the glycosidic linkage (C- vs. N-glycoside) in determining the nucleoside conformation.

PROCESS TO PREPARE MALAYAMYCIN DERIVATIVES

A process is provided for the preparation of a compound of the general formula (I): wherein R is H or C1-4 alkyl, which comprises treating a compound of the general formula (II): where R" is R or R8CO, R is as defined above, R8

A practical synthesis of the modified RNA nucleoside pseudouridine

An alternative synthesis of the modified RNA nucleoside pseudouridine is reported. This procedure employs coupling of an iodinated pyrimidine and a suitably protected lactone. The resulting hemiacetal is reduced and deprotected to yield pseudouridine.