73718-01-1Relevant academic research and scientific papers
Comparison between porphin, chlorin and bacteriochlorin derivatives for photodynamic therapy: Synthesis, photophysical properties, and biological activity
Zhu, Wei,Gao, Ying-Hua,Liao, Ping-Yong,Chen, Dan-Ye,Sun, Ning-Ning,Nguyen Thi, Phuong Anh,Yan, Yi-Jia,Wu, Xiao-Feng,Chen, Zhi-Long
, p. 146 - 156 (2018/10/21)
The development of novel photosensitizers is a challenging task for photodynamic therapy (PDT). Twelve novel photosensitizers (PSs), including porphins (P1-4), chlorins (C1-4) and bacteriochlorins (B1-4) were synthesized. The bacteriochlorins exhibited the longest absorption wavelength (λmax = 736 nm), which is higher than that of porphins (λmax = 630 nm) and chlorins (λmax = 644 nm). In vitro photodynamic activities on Eca-109 human esophageal carcinoma cells were evaluated by standard assays and all PSs showed photodynamic activity. Among them, B2 displayed the highest phototoxicity and the lowest dark toxicity. In addition, B2 exhibited best photodynamic antitumor efficacy on BALB/c nude mice bearing Eca-109 cells tumor. Therefore, B2 is a powerful and promising antitumor photosensitizer for PDT.
Utilities of olefin derivatives
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Page/Page column 12, (2008/06/13)
Compounds having an activity to enhance the expression of apoAI are provided. Compounds of formula (I): in which Ar1 and Ar2 are independently a phenyl, naphthyl, or monocyclic or bicyclic aromatic heterocyclic group, which may be optionally substituted; —X— is —N═CZ2-, —CY2═CZ2-, —CY2Y3—CHZ2-, —S—, —O—, or the like; Y1, Y2, Y3, Z1 and Z2 are independently a hydrogen, a halogen, a lower alkyl, a phenyl, or the like; Z1 and Z2 may be independently a linker group that may combine with Ar2 and Ar1 to form a condensed ring; m is 0 or 1, and n is 0 to 2; a prodrug thereof, a pharmaceutically acceptable salt or solvate of them; are disclosed.
New amino acid porphyrin derivatives. Part I: Synthesis
Perree-Fauvet, Martine,Verchere-Beaur, Catherine,Tarnaud, Eric,Anneheim-Herbelin, Gilles,Bone, Nathalie,Gaudemer, Alain
, p. 13569 - 13588 (2007/10/03)
In order to obtain molecules that can bind to specific DNA-sequences, several new tri-(N-methyl-4-pyridiniumyl)porphyrins bearing an amino acid or peptide side-chain on the fourth meso aromatic substituent have been synthesized by efficient coupling of a
PYRIMIDONE DERIVATIVES
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, (2008/06/13)
Compounds of the formula (I) STR1 in which R 1 and R. sub.2 each may represent hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, or alkyl, substituted by hydroxy, C 1-3 alkoxy, amino, C 1-3 alkylamino or di-C 1-3 alkylamino or R 1 and R 2 together with the nitrogen atom to which they are attached form an alicyclic heterocyclic ring which may be unsubstituted or may be substituted by one or more C 1-3 alkyl groups or a hydroxy group and/or may contain another heteroatom are described.Alk is a straight lower alkylene chain,Q is a furan or thiophen ring, the furan ring optionally bearing a further substituent R 5 adjacent to the group R 1 R 2 NAlk--or Q represents a benzene ring. R 5 represents halogen or C 1-3 alkyl which may be substituted by a hydroxy or C 1-3 alkoxy group;X represents--CH 2--,--O--or--S--;n represents zero or 1;m represents 2, 3 or 4;Y represents =O or =S;R 3 represents hydrogen in which case R 4 represents methyl or R 3 represents--(CH 2) p V(CH 2) q Ar, phenyl, or alkyl in which case R. sub.4 represents hydrogen;V represents--CH 2--,--O--, or--S--;p represents zero, 1, 2 or 3; q represents zero, 1, 2 or 3;the sum of p+q being 3 or less;Ar represents an aromatic carbocyclic or heterocyclic ring being optionally substituted by at least one C 1-3 alkyl, C 1-3 alkoxy C 1-3 alkyl, hydroxy, C 1-3 alkoxy, methylenedioxy, halogen, trifluoromethyl or di-C 1-3 alkylamino group; except that when n is zero and X is oxygen then Q represents a benzene or thiophen ring. The compounds of formula (I) have pharmacological activity as selective histamine H 2-antagonists.
