7372-07-8Relevant academic research and scientific papers
Synthesis and antimycobacterial activity of isoniazid derivatives from renewable fatty acids
Rodrigues, Marieli O.,Cantos, Jéssica B.,D'Oca, Caroline R. Montes,Soares, Karina L.,Coelho, Tatiane S.,Piovesan, Luciana A.,Russowsky, Dennis,Da Silva, Pedro A.,D'Oca, Marcelo G. Montes
, p. 6910 - 6914 (2013/11/06)
This work describes the synthesis of a series of fatty acid hydrazide derivatives of isoniazid (INH). The compounds were tested against Mycobacterium tuberculosis H37Rv (ATCC 27294) as well as INH-resistant (ATCC 35822 and 1896 HF) and rifampicin-resistant (ATCC 35338) M. tuberculosis strains. The fatty acid derivatives of INH showed high antimycobacterial potency against the studied strains, which is desirable for a pharmaceutical compound, suggesting that the increased lipophilicity of isoniazid plays an important role in its antimycobacterial activity.
Compound and use
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, (2008/06/13)
A compound contains a ligand group and at least one group of the general formula --XRn where X is a linking group which contains at least one hetero-atom, R is a saturated hydrocarbyl group containing at least six carbon atoms or is an unsaturated hydrocarbyl group containing at least three carbon atoms. The ligand group can be a polyhydroxyhydrocarbyl, a triazole, an imidazole, an indazole, a thiazole, an oxazole, a carbamate, an xanthate or a phthalazine. The compounds can be used to improve bonding between a metal and a coating material in contact with the metal surface. The metal may be a tire cord and the coating material rubber or a rubber composition.
