73725-25-4Relevant academic research and scientific papers
A Keggin heteropoly acid as an efficient catalyst for an expeditious, one-pot synthesis of 1-methyl-2-(hetero)arylbenzimidazoles
Chakrabarty, Manas,Mukherji, Ajanta,Mukherjee, Ratna,Arima, Shiho,Harigaya, Yoshihiro
, p. 5239 - 5242 (2008/02/08)
The Keggin heteropoly acid, silicotungstic acid, H4SiW12O40, has been demonstrated to be highly efficient for an expeditious, one-pot synthesis of 1-methyl-2-(hetero)arylbenzimidazoles from N-methyl-1,2-phenylenediamine and (hetero)aryl aldehydes in ethyl acetate at room temperature. The catalyst works equally well for N-phenyl-1,2-phenylenediamine.
RESEARCH ON THE CHEMISTRY OF 2-HETARYLBENZIMIDAZOLES. 2. SYNTHESIS AND PROPERTIES OF 1-METHYL-2-(1'-METHYL-2'-PYRROLYL)BENZIMIDAZOLE
El'chaninov, M.M.,Simonov, A.M.,Oleinikova, L.Ya.
, p. 59 - 61 (2007/10/02)
The condensation of 1-methyl-2-formylpyrrole with o-phenylenediamine gave 2-(1'-methyl-2'-pyrrolyl)benzimidazole, which was subjected to methylation.The alkylation product was subjected to electrophilic substitution.The substituent is incorporated in the 4 or 5 position of the hetaryl ring; however, bromination of 1-methyl-2-(1'-methyl-2'-pyrrolyl)benzimidazole leads to the formation of the mono-, di-, and tribromo derivatives, depending on the conditions.The acidophobic properties of the pyrrole ring are partially lost as a consequence of the effect of the benzimidazole ring.
