73733-83-2

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-[[[[2-[(phenylmethyl)amino]-3-pyridinyl]amino]thioxomethyl]amino]-, ethyl ester
• CAS NO: 73733-83-2
• Molecular Formula: C21H27N5O2S
• Molecular Weight: 413.544
• Mol File: 73733-83-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-[[[[2-[(phenylmethyl)amino]-3-pyridinyl]amino]thioxomethyl]amino]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-[[[[2-[(phenylmethyl)amino]-3-pyridinyl]amino]thioxomethyl]amino]-, ethyl ester(73733-83-2)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-[[[[2-[(phenylmethyl)amino]-3-pyridinyl]amino]thioxomethyl]amino]-, ethyl ester(73733-83-2)

Safety Data

• Hazardous Substances Data: 73733-83-2(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 3723-70-4 benzyl-(3-nitro-pyridin-2-yl)-amine 

Downstream Products

• 73734-02-8 ethyl 4-[3-(phenylmethyl)-3H-imidazo[4,5-b]pyridin-2-ylamino]-1-piperidinecarboxylate 
• 76031-50-0 3-(phenylmethyl)-N-(4-piperidinyl)-3H-imidazo[4,5-b]pyridin-2-amine 
• 98331-30-7 4-[4-(3-Benzyl-3H-imidazo[4,5-b]pyridin-2-ylamino)-piperidin-1-yl]-N,N-dimethyl-2,2-diphenyl-butyramide 
• 98331-31-8 1-{3-[4-(3-Benzyl-3H-imidazo[4,5-b]pyridin-2-ylamino)-piperidin-1-yl]-propyl}-1,3-dihydro-benzoimidazol-2-one 
• 98331-32-9 2-[4-(3-Benzyl-3H-imidazo[4,5-b]pyridin-2-ylamino)-piperidin-1-yl]-N-(2,6-dimethyl-phenyl)-acetamide 
• 73735-74-7 4-fluoro-N-[2-{4-[3-(phenylmethyl)-3H-imidazo[4,5-b]pyridin-2-ylamino]-1-piperidinyl}ethyl]benzamide 
• 73735-21-4 (3-Benzyl-3H-imidazo[4,5-b]pyridin-2-yl)-[1-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-piperidin-4-yl]-amine 
• 73735-26-9 4-[4-(3-Benzyl-3H-imidazo[4,5-b]pyridin-2-ylamino)-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one 
• 73755-86-9 (3-Benzyl-3H-imidazo[4,5-b]pyridin-2-yl)-{1-[3-(4-fluoro-phenoxy)-propyl]-piperidin-4-yl}-amine 
• 75970-98-8 (3-Benzyl-3H-imidazo[4,5-b]pyridin-2-yl)-{1-[2-(4-methoxy-phenyl)-ethyl]-piperidin-4-yl}-amine 
• 73735-24-7 (3-Benzyl-3H-imidazo[4,5-b]pyridin-2-yl)-[1-(2-morpholin-4-yl-ethyl)-piperidin-4-yl]-amine 
• 73735-18-9 (3-Benzyl-3H-imidazo[4,5-b]pyridin-2-yl)-[1-(2-phenoxy-ethyl)-piperidin-4-yl]-amine 
• 73735-25-8 (3-Benzyl-3H-imidazo[4,5-b]pyridin-2-yl)-[1-((E)-3-phenyl-allyl)-piperidin-4-yl]-amine 
• 73735-12-3 (3-Benzyl-3H-imidazo[4,5-b]pyridin-2-yl)-(1-phenethyl-piperidin-4-yl)-amine 

Relevant articles and documents

New Antihistaminic N-Heterocyclic 4-Piperidinamines. 3. Synthesis and Antihistaminic Activity of N-(4-Piperidinyl)-3H-imidazopyridin-2-amines

To study the bioisosteric replacement of a 2-pyridyl ring for a phenyl nucleus in astemizole, a series of N-(4-piperidinyl)-3H-imidazopyridin-2-amines was synthesised and evaluated.The title compounds were obtained starting from either 8a or 8b by four synthetic methods.The in vivo antihistamine activity was evaluated by the compound 48/80-induced lethality test in rats and the histamine-induced lethality test in guinea pigs after oral and/or subcutaneous administration.Compound 37, the isostere of astemizole, showed the most potent antihistaminic properties in the rat.However, astemizole is superior to 37 as to duration of action and total potency.