73733-99-0

Upstream product

• 5470-18-8 2-Chloro-3-nitropyridine 
• 140-75-0 para-fluorobenzylamine 
• 73733-74-1 N-<(4-fluorophenyl)methyl>-3-nitro-2-pyridinamine 
• 73733-75-2 N²-<(4-fluorophenyl)methyl>-2,3-pyridinamine 
• 75971-36-7 ethyl 4-<<<<2-<<(4-fluorophenyl)methyl>amino>-3-pyridinyl>amino>thioxomethyl>amino>-1-piperidine carboxylate 

Downstream Products

• 75979-00-9 3-<(4-fluorophenyl)methyl>-N-(4-piperidinyl)-3H-imidazo<4,5-b>pyridin-2-amine 
• 98331-33-0 {1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-[3-(4-fluoro-benzyl)-3H-imidazo[4,5-b]pyridin-2-yl]-amine 
• 73735-33-8 1-(3-{4-[3-(4-Fluoro-benzyl)-3H-imidazo[4,5-b]pyridin-2-ylamino]-piperidin-1-yl}-propyl)-1,3-dihydro-benzoimidazol-2-one 
• 73735-00-9 1-Ethyl-4-(2-{4-[3-(4-fluoro-benzyl)-3H-imidazo[4,5-b]pyridin-2-ylamino]-piperidin-1-yl}-ethyl)-1,4-dihydro-tetrazol-5-one 
• 73755-85-8 4-{4-[3-(4-Fluoro-benzyl)-3H-imidazo[4,5-b]pyridin-2-ylamino]-piperidin-1-yl}-1-(4-fluoro-phenyl)-butan-1-one 
• 73755-88-1 3-<(4-fluorophenyl)methyl>-N-<1-<2-(4-methoxyphenyl)ethyl>-4-piperidinyl>-3H-imidazo<4,5-b>pyridin-2-amine 
• 73734-60-8 [3-(4-Fluoro-benzyl)-3H-imidazo[4,5-b]pyridin-2-yl]-[1-(3-phenoxy-propyl)-piperidin-4-yl]-amine 
• 73735-68-9 3-(4-fluorophenylmethyl)-N-{1-[2-(2-thienyl)ethyl]-4-piperidinyl}-3H-imidazo[4,5-b]pyridin-2-amine 
• 73734-78-8 [3-(4-Fluoro-benzyl)-3H-imidazo[4,5-b]pyridin-2-yl]-[1-((E)-3-phenyl-allyl)-piperidin-4-yl]-amine 
• 73735-72-5 3-<(4-fluorophenyl)methyl>-N-<1-<2-(2-pyridinyl)ethyl>-4-piperidinyl>-3H-imidazo<4,5-b>pyridin-2-amine 
• 73734-48-2 [3-(4-Fluoro-benzyl)-3H-imidazo[4,5-b]pyridin-2-yl]-(1-phenethyl-piperidin-4-yl)-amine 

Relevant academic research and scientific papers

New Antihistaminic N-Heterocyclic 4-Piperidinamines. 3. Synthesis and Antihistaminic Activity of N-(4-Piperidinyl)-3H-imidazopyridin-2-amines

To study the bioisosteric replacement of a 2-pyridyl ring for a phenyl nucleus in astemizole, a series of N-(4-piperidinyl)-3H-imidazopyridin-2-amines was synthesised and evaluated.The title compounds were obtained starting from either 8a or 8b by four synthetic methods.The in vivo antihistamine activity was evaluated by the compound 48/80-induced lethality test in rats and the histamine-induced lethality test in guinea pigs after oral and/or subcutaneous administration.Compound 37, the isostere of astemizole, showed the most potent antihistaminic properties in the rat.However, astemizole is superior to 37 as to duration of action and total potency.

N-Heterocyclyl-4-piperidinamines

Novel N-heterocyclyl-4-piperidinamines wherein said heterocyclic radical is an optionally substituted 1H-benzimidazol-2-yl or 3H-imidazo[4,5-b]pyridin-2-yl radical, said compounds being useful as antihistaminic agents.