73737-68-5Relevant academic research and scientific papers
Enantioselective thiourea-catalyzed intramolecular cope-type hydroamination
Brown, Adam R.,Uyeda, Christopher,Brotherton, Carolyn A.,Jacobsen, Eric N.
supporting information, p. 6747 - 6749 (2013/06/05)
Catalysis of Cope-type rearrangements of bis-homoallylic hydroxylamines is demonstrated using chiral thiourea derivatives. This formal intramolecular hydroamination reaction provides access to highly enantioenriched α-substituted pyrrolidine products and represents a complementary approach to metal-catalyzed methods.
INTRAMOLECULAR N-ALKENYLNITRONE-ADDITIONS. REGIO- AND STEREOCHEMISTRY
Oppolzer, W.,Siles, S.,Snowden, R. L.,Bakker, B. H.,Petrzilka, M.
, p. 3497 - 3509 (2007/10/02)
Efficient intramolecular cycloadditions of N-3-alkenyl- and N-4-alkenylnitrones proceed with opposite regioselection which is modified by dipolarophile-substituent effects.Polycyclic isoxazolidines are obtained in a highly stereocontrolled fashion, consistent with an endo-addition of the Z-nitrones.
