7374-53-0Relevant academic research and scientific papers
Identification of disinfection by-products of selected triazines in drinking water by LC-Q-ToF-MS/MS and evaluation of their toxicity
Brix, Rikke,Bahi, Neus,De Alda, Maria J. Lopez,Farre, Marinella,Fernandez, Josep-Maria,Barcelo, Damia
experimental part, p. 330 - 337 (2010/06/17)
During the development of an on-line solid phase extraction-liquid chromatography-ultraviolet detection (SPE-LC-UV) analytical method for determination of eight selected triazines; ametryn, atrazine, cyanazine, metrybuzine, prometryn, propazin, simazine, and terbutryn, in drinking water, it was observed that the retention times of three of them (ametryn, prometryn, and terbutryn) in Milli-Q water were different from those in chlorinated Milli-Q water, indicating the formation of new products. The cause of this change was found in the oxidation of the molecules as a result of chlorination with sodium hypochlorite. Experiments performed at varying concentrations of triazines and hypochlorite showed that the extent of the reaction depended on their relative concentrations. At the maximum admissible level of 100 ng/l for individual pesticides in drinking water, no apparent transformation was observed in the absence or at low concentrations (0.05 mg/l) of hypochlorite; however, on increasing the concentration of hypochlorite to the level typically present in drinking water (0.9 mg/l) the transformation was complete. The reaction is quite fast; within 1 h the parent compound is completely degraded and after 22 h the concentrations of the by-products are constant. Investigation of the by-products by ultra performance liquid chromatography-quadrupole-time of flight- tandem mass spectrometry (UPLC-Q-ToF-MS/MS) has shown that all three triazines follow a similar transformation pathway, forming four new molecules whose structure have been elucidated. The acute toxicity of the new products was investigated using a standard method based on the bioluminescence inhibition of Vibrio fischeri, and the by-products showed a higher toxicity than that of the parent compounds. Copyright
Prometryne Oxidation by Sodium Hypochlorite in Aqueous Solution: Kinetics and Mechanism
Mascolo, G.,Lopez, A.,Foeldenyi, R.,Passino, R.,Tiravanti, G.
, p. 2987 - 2991 (2007/10/03)
The reaction of the herbicide prometryne (C9H16N5-C-CH3) with sodium hypochlorite has been investigated from the kinetic and mechanistic stand point. Under the fixed experimental conditions: pH = 7, T = 25 deg C [NaClO]/[substrate] = (1E-3 M)/(1E-5 M), prometryne oxidation takes place according to the following pathway: R-S-CH3 (P) -> R-SO-CH3 (a) -> R-SO2-CH3 (b) -> R-O-SO2-CH3 (x) -> R-OH (c), where R stands for C9H16N5, i.e., the substituted triazine ring of prometryne and (x) is an unexpected intermediate never previously detected nor identified. After having synthsized the pure intermediates (a), (b), and (x), the values of the pseudo-first-order kinetic constants of the first three steps were experimentally obtained: [k1 = (0.64 +/- 0.03) s-1, k2 = (1.81 +/- 0.05)E-3 s-1, k3 = (1.50 +/- 0.03)E-4 s-1]. As for k4, its value [(2.5 +/- 0.2)E-5 s-1] has been calculated indirectly on the basis of the kinetic theory concerning consecutive reactions. All the steps were pseudo-first-order reactions with respect to their specific substrate. the effect of pH on the hydrolysis of (b) [(b) -> (c)], in the absence of NaClO, has been also assessed to better elucidate the mechanism of the overall pathway.
