7375-42-0Relevant academic research and scientific papers
Synthesis and reactivity of 2-thionoester pyrroles: A route to 2-formyl pyrroles
Kim, Min Joon,Gaube, Sophie M.,Beh, Michael H. R.,Smith, Craig D.,Thompson, Alison
, p. 31773 - 31780 (2019/10/19)
2-Functionalised pyrroles exhibit considerable synthetic utility. Herein, the synthesis and reactivity of 2-thionoester (-C(S)OR) pyrroles is reported. 2-Thionoester pyrroles were synthesised using a Knorr-type approach from aliphatic starting materials. 2-Thionoester pyrroles were reduced to the corresponding 2-formyl pyrroles, or the deuterated formyl variant, in one step using RANEY nickel, thereby removing the need for the much-utilised hydrolysis/decarboxylation/formylation steps that are typically required to convert Knorr-type 2-carboxylate pyrroles into 2-formyl pyrroles. 2-Thionoester pyrroles proved tolerant of typical functional group interconversions for which the parent 2-carboxylate pyrroles have become known.
Synthesis of symmetric meso-H-dipyrrin hydrobromides from 2-formylpyrroles
Lund, Kate-Lyn A. R.,Thompson, Alison
supporting information, p. 1142 - 1144 (2014/05/20)
The reaction of 2-formylpyrroles in acidic methanol gives the corresponding symmetric, meso-H-4,6-dipyrrin hydrobromides. This convenient strategy involves initial deformylation under the acidic conditions, followed by immediate in situ reaction of the re
