73750-45-5

Upstream product

• 507-20-0 tertiary butyl chloride 
• 100-01-6 4-nitro-aniline 
• 107-13-1 acrylonitrile 

Downstream Products

• 73750-41-1 N-tert-Butyl-3-butylsulfanyl-N'-(4-nitro-phenyl)-propionamidine 
• 73750-37-5 N-tert-Butyl-N'-(4-nitro-phenyl)-3-phenylsulfanyl-propionamidine 
• 125986-49-4 N-tert-Butyl-N'-(4-nitro-phenyl)-3-(2-oxo-cyclopentyl)-propionamidine 
• 80281-73-8 N-tert-Butyl-3-diisopropylamino-N'-(4-nitro-phenyl)-propionamidine 
• 80281-79-4 N-tert-Butyl-N'-(4-nitro-phenyl)-3-(4-nitro-phenylamino)-propionamidine 
• 125986-43-8 N-tert-Butyl-N'-(4-nitro-phenyl)-3-(2-oxo-cyclohexyl)-propionamidine 
• 125986-53-0 N-tert-Butyl-N'-(4-nitro-phenyl)-3-(2-piperidin-1-yl-cyclopent-2-enyl)-propionamidine 
• 80281-60-3 N-tert-Butyl-N'-(4-nitro-phenyl)-3-piperidin-1-yl-propionamidine 

Relevant academic research and scientific papers

THE MICHAEL ADDITION OF ENAMINES TO PROPENAMIDINES. A CONVENIENT SYNTHESIS OF 2-β-AMIDINOETHYLCYCLOALKANONES BY AMIDINOETHYLATION REACTION

A variety of propenamidines 3 have been reacted with enamines of cyclopentanone and cyclohexanone giving after hydrolysis of the Stork enamine 6, 2-β-amidinoethylcyclopentanones 8 and -hexanones 7.This reaction illustrates the electrophilic character of the C=C double bond due to the conjugated amidine function, thus providing with propenamidines 3 a new class of Michael acceptors for enamines.

SYNTHESE DE NOUVELLES PROPENAMIDINES N-SUBSTITUEES A PARTIR DE SELS DE NITRILIUM

A number of N-t-butylpropenamidines V have been prepared for the first time by amination of N-t-butylacrylonitrilium (IIIb) or N-t-butylmethacrylonitrilium tetrachloroferrate (IIIc).The salts IIIb and IIIc are easily prepared at -40 deg C within a few minutes from the corresponding nitrile, t-butyl chloride and ferric chloride.The amination (with primary or secondary aliphatic or aromatic amines) should be started at -70 deg C to ensure a smooth reaction and to give high yields of amidine V, because the nitrilium salts are unstable above -10 deg C.This method represents an easy one-pot synthesis of N-t-butyl substituted propenamidines from the corresponding nitrile I.