73751-45-8Relevant academic research and scientific papers
ASYMMETRIC SYNTHESIS OF CYCLOALKANO-2,3-PIPERID-4-OLS
Grishina, G.V.,Potapov, V.M.,Gudasheva, T.A.
, p. 86 - 88 (1980)
A new method for the asymmetric synthesis of cycloalkano-2,3-piperid-4-ols by the reaction of a number of chiral enamino ketones with sodium borohydride is proposed.It is shown that the reduction proceeds via 1,4-hydride addition and leads to the formation of primarily one diastereomeric pair of cycloalkano-2,3-popiridols and their dehydration products.The asymmetric synthesis was confirmed by the production of optically active nitrogen-unsubstituted cycloalkano-2,3-piperid-4-ols when the chiral substituent was removed.
