73751-61-8Relevant academic research and scientific papers
Total Synthesis of -Mitrephorone A
Richter, Matthieu J. R.,Schneider, Michael,Brandst?tter, Marco,Krautwald, Simon,Carreira, Erick M.
, p. 16704 - 16710 (2018/12/14)
The first synthesis of mitrephorone A is disclosed along with discussion and study of synthetic strategies. The natural product includes a highly congested hexacyclic ent-trachylobane diterpenoid framework featuring a rare, embedded oxetane. The synthetic analysis presented dissects a number of approaches for the synthesis of the central oxetane, including carbonyl-olefin photocycloadditions, Prins-type cyclizations, and oxidative ring closures. In the successful route, three [4 + 2] cycloadditions enable rapid construction of all carbocycles. A novel late-stage oxidative cyclization of a hydroxy diosphenol with Koser's reagent furnishes the pivotal oxetane moiety.
Efficient Syntheses of a New Chiral Diene and a New Bridgehead Enone for a Diels-Alder Approach to Kaura-9(11)-16-dien-19-oic Acid
Huang, P. Q.,Zhou, W. S.
, p. 875 - 878 (2007/10/02)
Efficient syntheses of a new chiral diene and a new bridgehead enone for a Diels-Alder approach to kaura-9(11)-di-en-19-oic acid (1) are described.
Substituent Effects on the Stereochemistry of Substituted Cyclohexanone Dimethylhydrazone Alkylations. An X-ray Crystal Structure of Lithiated Cyclohexanone Dimethylhydrazone
Collum, David B.,Kahne, Daniel,Gut, Sally A.,DePue, Randall T.,Mohamadi, Fariborz,et al.
, p. 4865 - 4869 (2007/10/02)
Substituent effects on the alkylations of the dimethylhydrazones of 2,4- and 2,6-disubstituted cyclohexanones are reported.High axial selectivities are observed in the alkylations of cyano-substituted metalated hydrazones, but not with alkoxycarbonyl-subs
