73768-81-7Relevant academic research and scientific papers
Synthesis and antithyroid activity of triazole derivatives
Lagorce,Comby,Buxeraud,Raby
, p. 359 - 368 (2007/10/02)
The synthesis of nitrogen heterocycle derivatives (pyridine, pyrimidine, pyrazine) of 3-mercapto-1,2,4-triazole and 3-mercapto-1-methyl-1,2,4-triazole is described. The antithyroid activity of compounds is evaluated by action on molecular iodine, by action on peroxidase and in vivo on the rat (hormones levels, histology). Pyridyl and pyrimidyl derivatives of mercaptotriazole and mercaptomethyltriazole, as well as (6-methoxy-pyridyl) mercaptomethyltriazole, are the most active. Study over one month does not reveal agranulocytosis.
Synthesis and inhibitory effects of 1,2,4-triazole derivatives on platelet aggregation
Lagorce,Moulard,Raby
, p. 314 - 318 (2007/10/02)
Various derivatives of triazole substituted in the 2-position were prepared, and their activity on platelet aggregation tested. Compounds 4 and 14 had the most powerful action. These agents were thought to inhibit platelet aggregation via an inhibition of the cyclo-oxygenase-peroxidase complex (PGS complex), preventing synthesis of prostaglandins.
