737742-80-2

Basic information

• Product Name: 2-benzyl-1,3-diazaspiro[4.4]non-1-en-4-one
• Synonyms: 2-benzyl-1,3-diazaspiro[4.4]non-1-en-4-one
• CAS NO: 737742-80-2
• Molecular Weight: 228.294
• Mol File: 737742-80-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-benzyl-1,3-diazaspiro[4.4]non-1-en-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzyl-1,3-diazaspiro[4.4]non-1-en-4-one(737742-80-2)
• EPA Substance Registry System: 2-benzyl-1,3-diazaspiro[4.4]non-1-en-4-one(737742-80-2)

Safety Data

• Hazardous Substances Data: 737742-80-2(Hazardous Substances Data)

Upstream product

• 17193-28-1 1-aminocyclopentane-1-carboxamide 
• 103-80-0 phenylacetyl chloride 

Relevant articles and documents

Discovery of Irbesartan Derivatives as BLT2 Agonists by Virtual Screening

Leuktriene B4 receptor 2 (BLT2) is a G-protein coupled receptor modulation of which is discussed to be a therapeutic option for healing of intestinal lesions. In this work, new BLT2 agonists were identified by a virtual screening of a repurposing library and in vitro assay of the most promising compounds. Irbesartan, an approved type-1 angiotensin II receptor (AT1) antagonist, was identified as a moderate BLT2 agonist. An initial SAR study on the irbesartan scaffold was performed resulting in the discovery of a new potent BLT2 agonist (8f, EC50 = 67.6 nM). Irbesartan and 8f were shown to promote proliferation of epithelial colon cells, an effect which was reversible by a BLT2 antagonist.