73775-88-9Relevant academic research and scientific papers
Synthesis and blood pressure lowering activity of 3-(substituted-amino)-1,2,4-benzothiadazine 1-oxide derivatives
Dillard,Yen,Stark,Pavey
, p. 717 - 722 (2007/10/02)
A series of (substituted amino)-1,2,4-benzothiadiazine 1-oxides has been synthesized and most members of the series have been shown to have blood-pressure lowering effects in normotensive rabbits and in spontaneously hypertensive rats. The most active member of the series was 3-[4-(2-furoyl)-1-piperazinyl]-6,7-dimethoxy-1-methyl-1H-1,2,4-benzothiadiazine 1-oxide hydrochloride. This compound in animal tests was equipotent to the known antihypertensive Prazosin.
